Korean J Gastroenterol.
2000 Jan;35(1):132-136.
A Case of Primary 's Syndrome Associated with Autoimmune Chronic Active Hepatitis
Abstract
- Sjogren's syndrome is a chronic inflammatory disorder characterized by lymphocytic infiltration of lacrimal and salivary glands. Although it may involve other extra-glandular organs, the involvement of the liver is observed rarely. Here, we report a rare case of primary Sjogren's syndrome associated with autoimmune chronic active hepatitis. A 38-year-old woman was admitted to our hosipital due to jaundice and itching sensation. Serologic viral markers were all negative. Laboratory data showed increased serum immunoglobulin G level and anti-nuclear antibody titer. Both anti-Ro and anti-La antibody were positive. Anti-mitochondrial antibody, anti-smooth muscle antibody and antibody against liver kidney microsome were all negative. The characteristic clinical manifestations, results of Schirmer's test, and histologic fingings of minor salivary gland were compatible with primary Sjogren's syndrome. She was diagnosed as an autoimmune chronic active hepatitis on the basis of clinical features and histologic findings of liver biopsy specimen. The patient was treated with predisolone, demonstrating improvement in clinical and liver function indices.
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