Korean J Epidemiol.  2000 Jun;22(1):59-67.

The Role of Genetic Polymorphism of Cytochrome P450 2E1 in Bladder Cancer in Korea

Affiliations
  • 1Department of Preventive Medicine, Seoul National University College of Medicine.
  • 2Institute of Environmental Medicine, Medical Research Center, Seoul National University College of Medicine.
  • 3Department of Urology, Seoul National University College of Medicine.
  • 4Department of Internal Medicine, Hallym University College of Medicine.
  • 5Department of Urology, Sungkyunkwan University College of Medicine.

Abstract

Although the association of genetic polymorphisms in glutathione S-transferase(GST) and N-acetyltransferase(NAT) with bladder cancer has been reported, limited numbers of studies have been indicated the association of CYP2E1 with bladder cancer, particularly in Asian population. A hospital based case-control study was conducted in South Korean, consisting of 232 histologically confirmed prevalent bladder cancer cases and 165 controls to evaluate the association between genetic polymorphisms of CYP2E1(RsaI) and development of bladder cancer. The frequency of CYP2E1(RsaI) c1/c1 genotype in bladder cancer cases was higher than in controls; 114 of 201(56.7%) vs. 62 of 146(42.5%). Men with CYP2E1(RsaI) c1/c1 genotype had increased risk of development of bladder cancer compared to men with at least one c2 allele(OR=1.7, 95% CI=1.1-2.7). The bladder cancer risk increased as the number of c1 allele increased(p for trend=0.005). The risk increased as the amount of smoking increased(p for trend=0.009). When data were analyzed for the interaction between smoking and CYP2E1 genetic polymorphisms, smokers with c1/c1 genotype have 2.5 greater risk in development of bladder cancer(95% CI=1.0-6.2) compared to nonsmokers with c2 allele(p for interaction=0.008). Our findings suggest that the interaction between genetic polymorphisms of CYP 2E1 (RsaI, c1/c1) and smoking may play an important role for development of bladder cancer among Koreans.

Keyword

CYP2E1; Genetic polymorphism; Bladder cancer; Case-control study

MeSH Terms

Alleles
Asian Continental Ancestry Group
Case-Control Studies
Cytochrome P-450 CYP2E1*
Cytochrome P-450 Enzyme System*
Cytochromes*
Genotype
Glutathione
Humans
Korea*
Male
Polymorphism, Genetic*
Smoke
Smoking
Urinary Bladder Neoplasms*
Urinary Bladder*
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Cytochromes
Glutathione
Smoke
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