Korean J Dermatol.  2000 Aug;38(8):1140-1143.

A Case of Allergic Contact Dermatitis Due to Topical Antifungal Cream

• Shim JH
• Choi HG
• Seo SJ
• Hong CK

Abstract

Propylene glycol, which is capable of producing both primary irritant and allergic skin reaction, is a common used vehicle for numerous topical preparations. The topical imidazole antimycotics are widely used but an infrequent cause of contact allergy. A 20-year-old female presented with erythematous scaly patch on the lower leg. An erythematous pruritic papulovesicular eruption developed around the lesion after applying Nizoral cream and was aggravated after applying Travogen cream. Patch test with Korean standard series and the ingredients of both cream revealed positive reaction to the propylene glycol contained in Nizoral cream and isoconazole nitrate in Travogen cream.

Keyword

Allergic contact dermatitis; Propylene glycol; Isoconazole nitrate

MeSH Terms

Dermatitis, Allergic Contact*
Female
Humans
Hypersensitivity
Ketoconazole
Leg
Patch Tests
Propylene Glycol
Skin
Young Adult
Ketoconazole
Propylene Glycol