Korean J Dermatol.
2004 Feb;42(2):189-194.
Neutrophilic Dermatoses Associated with Myelodysplastic Syndrome
- Affiliations
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- 1Department of Dermatology, College of Medicine and Gyeongsang Instiute of Health Science, Gyeongsang National University, Chinju, Korea. deroh@nongae.gsnu.ac.kr
Abstract
- Cutaneous involvement in myelodysplastic syndrome (MDS) is the form of either a neoplastic infiltration or various nonspecific lesions. The nonspecific lesions are more common and include cutaneous infection, vasculitis and neutrophilic dermatoses. The occurrence of these lesions may be the presenting feature of the disease (MDS) or may herald its progression to acute leukemia. Recognition and early diagnosis of any skin lesion in MDS patients have therapeutic and prognostic significance. We report a case of neutrophilic dermatoses associated with MDS in a 26-year-old man who presented with high fever, tender annular erythematous plaques with crust on the face and upper extremities. He was diagnosed as anemia and thrombocytopenia 3 months ago. Skin biopsy showed dense infiltration of neutrophils in the dermis. Bone marrow biopsy revealed dyspoiesis of marrow cells, consistent with MDS. It is important to investigate any skin involvement in MDS patients.
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