Korean J Dermatol.  1999 Jun;37(6):765-769.

A Case of Subcutaneous Sweet's Syndrome in MYelodysplastic Syndrome Showing Nuelear Segmentation Anomalies of Neutrophils

• Jeon YM
• Won JY
• Lee CH
• Kim MC
• Lee SJ
• Song ES

Abstract

We encountered a case of Sweet's syndrome associated with myelodysplastic syndrome in a 60-year-old woman. The clinical presentation strongly suggested Sweet's syndrome. A skin biopsy specimen taken from her skin lesion on the leg showed an infiltration of numerous neutrophils in the subcutis instead of the dermis which is the main area of neutrophilic infiltration in Sweet's syndrome. Among infiltrating cells, many neutrophils(8%) showed nuclear segmentation anomalies, that is, hyposegmentation(pseudo-Pelger-Huet anomaly) or hypersegmentation. Peripheral blood neutrophils had similar anomalies. This subcutaneous variant of Sweet's syndrome, Sweet's panniculitis, is rare and nuclear segmentation anomalies of neutrophils are probably a good clue to underlying myelodysplastic syndrome.

Keyword

Subcutaneous Sweet's syndrome; Sweet's panniculitis; Myelodysplastic syndrome; Nuclear segmenatation anomalies of neutrophils

MeSH Terms

Biopsy
Dermis
Female
Humans
Leg
Middle Aged
Myelodysplastic Syndromes*
Neutrophils*
Panniculitis
Skin
Sweet Syndrome*