Korean J Blood Transfus.  2013 Dec;24(3):207-216.

Platelet Additive Solutions

Affiliations
  • 1Blood Transfusion Research Institute, Korean Red Cross, Seoul, Korea. sykwon@redcross.or.kr
  • 2Blood Services Headquarters, Korean Red Cross, Seoul, Korea.

Abstract

Storage of platelet concentrates in platelet additive solution (PAS) with plasma removal has many advantages, including reduction of allergic reactions, contributing to the available plasma pool for fractionation or transfusion, and employment of pathogen reduction technology. In order to decrease platelet activation for improvement of in vivo viability, PAS should be designed for optimization of aerobic metabolism using compounds such as glucose, acetate, citrate, phosphate, and electrolytes. After a thorough discussion, particularly on the efficacy and regulations, use of the buffy coat method as well as application of a new generation of PAS may likely be the future direction of platelet storage in Korea.

Keyword

Platelet additive solution; Plasma; Buffy coat method

MeSH Terms

Blood Platelets*
Citric Acid
Electrolytes
Employment
Glucose
Hypersensitivity
Korea
Metabolism
Plasma
Platelet Activation
Social Control, Formal
Citric Acid
Electrolytes
Glucose
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