Korean J Anesthesiol.  2009 Jun;56(6):646-651. 10.4097/kjae.2009.56.6.646.

The effect of intraoperative colloid solutions coadministered with 6% hydroxyethyl starch (130/0.4) on platelet function in patients undergoing total intravenous anesthesia

• Cho HY
• Shin YS
• Son SC
• Lee SY
• Cho WH

• KMID: 2092195
• DOI: http://doi.org/10.4097/kjae.2009.56.6.646

Abstract

BACKGROUND: Colloid solutions are used to treat hypovolemia and expanding plasma, but they may inhibit platelet function and reduce the level of coagulation factors during surgery. This study was conducted to compare the effects of hydroxyethyl starch (HES) on adenosine diphosphate (ADP)- and collagen-induced platelet aggregation in patients undergoing total intravenous anesthesia.
METHODS
Patients undergoing endoscopic sinus surgery under total intravenous anesthesia with propofol and remifentanil were divided into a group that underwent fluid management with only crystalloid solution (n = 15) and a group that was managed with crystalloid solution that included 6% HES (130/0.4) (n = 15). ADP- and collagen-induced platelet aggregation were measured 5 minutes before induction, after the first intraoperative hour, and one hour postoperatively.
RESULTS
Significantly diminished ADP- and collagen-induced aggregation values were observed intraoperatively when compared with the preoperative value in the patients that were managed with colloid solution that included HES. In addition, significantly diminished collagen-induced aggregation values were observed intraoperatively when compared with the preoperative value in the group that was managed with the solution that only contained the crystalloid. However, ADP- and collagen-induced platelet aggregation were recovered postoperatively in both groups.
CONCLUSIONS
The results of this study indicated that fluid therapy with colloid solution that contained 6% HES (130/0.4) may diminish ADP-induced platelet aggregation intraoperatively in patients subjected to total intravenous anesthesia.

Keyword

Colloid solution; Crystalloid solution; Hydroxyethyl starch; Platelet function; Total intravenous anesthesia

MeSH Terms

Adenosine Diphosphate
Anesthesia, Intravenous
Blood Coagulation Factors
Blood Platelets
Colloids
Fluid Therapy
Hetastarch
Humans
Hypovolemia
Isotonic Solutions
Piperidines
Plasma
Platelet Aggregation
Propofol
Adenosine Diphosphate
Blood Coagulation Factors
Colloids
Hetastarch
Isotonic Solutions
Piperidines
Propofol