Korean J Asthma Allergy Clin Immunol.  2010 Sep;30(3):233-236.

Suspicious Eosinophilic Fasciitis Preceding Peripheral T Cell Lymphoma

Abstract

Eosinophilic fasciitis (EF) is characterized by scleroderma-like skin lesions, peripheral eosinophilia and hypergammaglobulinemia. While EF is generally benign course, it may precede hematologic malignancy or Hodgkin's disease, association with peripheral T-cell lymphoma (PTCL) is extremely rare. A 49-year-old man with edema and induration of both distal extremities. Peripheral blood eosinophil count was 2,530/microliter. We suspected EF, however, could not performed histological diagnosis due to his refusal. After 6 months, he was suffered of abrupt fever, weight loss and general weakness for 1 months. Erythematous nodular papules of skin and enlarged inguinal lymph nodes were noted. Biopsies from skin and lymph node showed peripheral T cell lymphoma.

MeSH Terms

Biopsy
Disulfiram
Edema
Eosinophilia
Eosinophils
Extremities
Fasciitis
Fever
Hematologic Neoplasms
Hodgkin Disease
Humans
Hypergammaglobulinemia
Lymph Nodes
Lymphoma
Lymphoma, T-Cell, Peripheral
Middle Aged
Skin
Weight Loss
Disulfiram
Eosinophilia
Fasciitis