Korean J Pathol.  2009 Oct;43(5):478-481. 10.4132/KoreanJPathol.2009.43.5.478.

Eosinophilic Fasciitis Associated with Overlying Intraepidermal Blister Formation: A Case Report

  • 1Department of Pathology, Gachon University Gil Hospital, Incheon, Korea. syha@gilhospital.com


Eosinophilic fasciitis is a scleroderma-like disease and it may present with paraneoplastic syndrome or as an isolated form of the disease. We report here on a case of eosinophilic fasciitis in a 20-year-old woman who presented with an abrupt onset of subcutaneous limb swelling and peripheral eosinophilia. Pathologically, the specimen was characterized by acute inflammation and thickening of the collagen bundles in the reticular dermis and superficial muscle fascia in addition to the overlying intraepidermal blisters that contained many eosinophils. Eosinophils, some lymphocytes and plasma cells were infiltrated in the superficial muscle fascia and subcutaneous fat. The diagnosis of eosinophilic fasciitis was confirmed by biopsy. It is intriguing that eosinophilic fasciitis showed the microscopic findings of intraepidermal blister with predominant inflammation, and the patient showed a good response to steroid therapy.


Eosinophilia; Fasciitis; Panniculitis; Blister
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