Korean J Asthma Allergy Clin Immunol.  2010 Sep;30(3):222-227.

The Stability of the Disk-type Microneedle in Skh-hairless-1 (Albino) Mice

Abstract

BACKGROUND
The transdermal drug delivery system has been studied for several decades as an alternative tool. Even though it has many advantages such as stability of drug to the destination, safety to the liver, there are some limitations in crossing the stratum corneum. Microneedle can perforate the skin directly, which make it possible for drugs to penetrate into the subcutaneous tissue.
OBJECTIVE
The purpose of this study to evaluate the stability of Diskmicroneedle Therapy System (DTS) and directly compare them with conventional Microneedle Therapy System (MTS(R), Clinical Resolution Lab, California, USA). METHOD: We used 3 sizes of manual and electric Diskmicroneedle Therapy System (DTS; 0.25 mm, 1.0 mm and 1.5 mm) to perforate the skin. We performed a comparative study of 0.5 mm manual DTS and Microneedle Therapy System (MTS(R)). To evaluate the stability, visual inspection and biopsy were conducted. RESULT: Manual and electric DTS of all 3 sizes did not induce significant abnormalities of the skin on visual inspection and biopsy. DTS and MTS produced similar results on the stability for the skin.
CONCLUSION
Similar to the preexisting MTS, DTS is a safe transdermal delivery system, and the size should be chosen carefully.


MeSH Terms

Animals
Biopsy
California
Drug Delivery Systems
Liver
Mice
Pyridines
Skin
Subcutaneous Tissue
Thiazoles
Pyridines
Thiazoles
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