Korean J Androl.  2012 Apr;30(1):45-51. 10.5534/kja.2012.30.1.45.

Comparison of Clinical Efficacy of Finasteride and Dutasteride as 5-alpha Reductase Inhibitor

• Choi H
• Chang YS
• Park BH
• Ko DH
• Moon YJ
• Kim JB

• KMID: 2298808
• DOI: http://doi.org/10.5534/kja.2012.30.1.45

Abstract

PURPOSE
To compare the clinical therapeutic efficacy of finasteride and dutasteride as 5-alpha reductase inhibitor (5-ARI) in the medical treatment of benign prostate hyperplasia.
MATERIALS AND METHODS
From July 2007 to July 2010, 354 benign prostatic hyperplasia patients with combination medication : alpha blocker plus 5-ARI were enrolled. These patients were classified into a finasteride medication group (F group) and dutasteride medication group (D group) retrospectively. We initially measured the total prostate volume (TPV), prostate specific antigen (PSA), International Prostate Symptom Score (IPSS), quality of life score (QoL), maximal flow rate (Qmax), and post-void residual urine (PVR). After at least twelve months of medication, we rechecked these clinical parameters and during medication, side effects related to medication were also recorded.
RESULTS
The F group (n=129) and D group (n=225) showed no differences in baseline characteristics for age, TPV, IPSS, QoL scores, or PSA. After medication, decreases in TPV were relatively higher in the D group than the F group (28.2% vs 20.5%). In addition, the decrease in PSA (43.6% vs 39.2%) and IPSS score (4.6 vs 3.5) were also higher in the D group. There were no significant differences in QoL score, Qmax, PVR change, or side effects between the two groups.
CONCLUSIONS
Dutasteride showed greater efficacy in reduction of TPV and PSA and in symptomatic improvement by IPSS score than finasteride. More large scale studies about the differences on clinical efficacy of finasteride and dutasteride are needed.

Keyword

Benign prostate hyperplasia; 5-alpha reductase inhibitors; Prostate volume

MeSH Terms

5-alpha Reductase Inhibitors
Azasteroids
Finasteride
Humans
Oxidoreductases
Prostate
Prostate-Specific Antigen
Prostatic Hyperplasia
Quality of Life
Retrospective Studies
Dutasteride
5-alpha Reductase Inhibitors
Azasteroids
Finasteride
Oxidoreductases
Prostate-Specific Antigen

Figure

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  Fig. 1. Comparison of changes in prostate volume and prostate specific antigen (PSA) after finasteride and dutasteride medication.

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  Fig. 2. Comparison of changes in International Prostate Symptom Score (IPSS) and quality of life (Qol) score after finasteride and dutasteride medication.

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