Korean J Androl.  2004 Apr;22(1):36-40.

Combination Therapy of Intraurethral Condyloma Acuminatum with Holmium: YAG Laser and 5-Fluorouracil Instillation

• Kim IW
• Cho IR
• Lee KC
• Jeon JS

Abstract

PURPOSE
Condyloma acuminatum is a common sexually transmitted disease of the external genitalia and anus. Approximately 5% of patients demonstrate urethral involvement. Electrical fulguration or excision using a pediatric resectoscope has been used in the management of such lesions. Holmium(Ho):YAG laser, 5-FU(fluorouracil), or interferon may be helpful in eradicating them. We reviewed the results of intraurethral condyloma acuminatum treatment with Ho:YAG laser and 5-FU solution.
MATERIALS AND METHODS
From January 2001 to July 2002, seven patients with intraurethral condylomata acuminata were enrolled in the study. The mean age of the subjects was 19.5(range 25~43) years. Under local anesthesia with 10% lidocaine spray and jelly, all of the intraurethral lesions were removed with the Ho:YAG laser followed by coverage with 10mL of 5% 5-FU solution. Intraurethral injection of 5-FU was performed weekly up to six times. Urethroscopy for detection of recurrence was done 3 months after initial laser therapy.
RESULTS
Most patients had multiple intraurethral lesions. Six patients (86%) responded to initial therapy without local recurrence with a mean follow-up of 15.8 (range 9.1-23.2) months. One patient had a recurrence at 2 months.
CONCLUSIONS
We believe that the Ho:YAG laser plus 5% 5-FU solution is a useful option for the treatment of intraurethral condyloma acuminatum.

Keyword

Condyloma acuminatum; 5-Fluorouracil; Holmium: YAG laser; Urethral lesions

MeSH Terms

Anal Canal
Anesthesia, Local
Condylomata Acuminata
Fluorouracil*
Follow-Up Studies
Genitalia
Holmium*
Humans
Interferons
Laser Therapy
Lasers, Solid-State*
Lidocaine
Recurrence
Sexually Transmitted Diseases
Fluorouracil
Holmium
Interferons
Lidocaine