Allergy Asthma Immunol Res.  2016 Sep;8(5):457-460. 10.4168/aair.2016.8.5.457.

Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria

Affiliations
  • 1Department of Dermatology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
  • 2Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
  • 3Department of Laboratory Medicine, Saga Medical School, Saga, Japan.
  • 4The Shino-Test Corporation, Sagamihara, Japan.
  • 5Department of Pharmacology and SBRI, Sungkyunkwan University School of Medicine, Suwon, Korea.
  • 6Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea. mdqueen@hallym.or.kr

Abstract

Chronic spontaneous urticaria (CSU) is a complex idiopathic disease of the skin with various cellular infiltrations. Although mast cells are key effector cells in the pathogenesis of CSU, CD4+ T helper 2 cells also have particular roles in the development and maintenance of CSU. Periostin is known as a downstream molecule of interleukin (IL)-4 and IL-13, key cytokines of type 2 immune responses. In this study, we examined periostin and IL-13 levels in the sera of patients with CSU (n=84) and healthy normal controls (NCs, n=43). Periostin levels were significantly lower in the CSU group than in NCs (71.4±21.8 vs 85.1±22.4 ng/mL, P=0.04). Periostin levels were also lower in the severe CSU group than those in mild CSU (59.7±18.0 vs 73.4±22.0 ng/mL, P=0.04). However, IL-13 levels were significantly higher in patients with CSU than in NCs (508.5±51.2 vs 200.7±13.3 pg/mL, P=0.001). In conclusion, periostin and IL-13 may be independently related to the pathogenesis of CSU.

Keyword

Urticaria; periostin; interleukin-13

MeSH Terms

Cytokines
Humans
Interleukin-13*
Interleukins
Mast Cells
Skin
Urticaria*
Cytokines
Interleukin-13
Interleukins

Figure

  • Fig. 1 (A) Serum periostin and (B) IL-13 levels in CSU patients and NCs. CSU, chronic spontaneous urticaria; NCs, normal controls.

  • Fig. 2 Comparison of periostin levels according to disease severity in CSU patients.


Cited by  1 articles

Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children
Dong Keon Yon, Jaewoo An, Eun Kyo Ha, Hye Mi Jee, Kenji Izuhara, Junya Ono, Young-Ho Jung, Kyung Suk Lee, Youn Ho Sheen, Heysung Baek, Man Yong Han
Allergy Asthma Immunol Res. 2018;10(6):716-721.    doi: 10.4168/aair.2018.10.6.716.


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