J Korean Acad Fam Med.  2002 Jul;23(7):917-924.

The Association of Abdominal Fat with Serum Insulin and Atherogenic Index for Obese Females

Affiliations
  • 1Department of Family Medicine, Inje University Medical School, Korea. Fmlky@ijnc.inje.ac.kr
  • 2Department of Preventive Medicine, Inje University Medical School, Korea.
  • 3Department of Nutrition, Inje University Medical School, Korea.

Abstract

BACKGROUND: The purpose of this study was to find an independent relationship between waist circumference/waist-to-hip ratio which estimates abdominal fat and fasting insulin/atherogenic index which is a predictor of coronary heart disease in obese women.
METHODS
The subjects were 80 obese (BMI > or = 25 kg/m2) women. Whole body fat was estimated by body fat mass, % body fat using bioelectrical impedence, and by BMI. Abdominal fat was measured by waist circumference (WC) and waist-to-hip ratio. Fasting insulin was examined and atherogenic index was defined asthe ratio of serum total cholesterol to HDL-cholesterol. Independent association between abdominal fat and insulin/AI was analyzed using partial correlation, multiple regression and Hotelling t-test.
RESULTS
Among subjects, 85.7% of obese women had WC greater or equal to 80 cm. The mean BMI was 30.3 kg/m2. The partial correlations between whole body fat and insulin/AI were not significantly different from the partial correlations between abdominal fat and insulin/AI. When age and height were adjusted, partial correlations between abdominal fat and insulin were 0.38 and 0.39. The partial correlations were reduced to 0.15-0.29 after further adjusting for whole body fat. Age and height-adjusted partial correlations between abdominal fat and AI were 0.34 and 0.36. The partial correlations were reduced to 0.11-0.17 when whole body fat was additionally adjusted. Whole body fat explained 9.9-13.7% for variability of insulin; abdominal fat explained 14.2% and 15.9%. Whole body fat explained 12.5-12.8% for variability of AI and abdominal fat explained 11.9%.
CONCLUSION
Most of the obese women showed abdominal obesity. Abdominal fat did not seem to be independently associated with fasting insulin and atherogenic index.

Keyword

abdominal fat; obesity; women; fasting insulin; atherogenic index

MeSH Terms

Abdominal Fat*
Adipose Tissue
Cholesterol
Coronary Disease
Fasting
Female*
Humans
Insulin*
Obesity
Obesity, Abdominal
Waist Circumference
Waist-Hip Ratio
Cholesterol
Insulin
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