Korean J Urol.
2003 Jul;44(7):697-701.
A Multicenter Study of Antimicrobial Susceptibility of Uropathogens Causing Acute Uncomplicated Cystitis in Woman
- Affiliations
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- 1Department of Urology, College of Medicine, Catholic University, Korea. cyh0831@catholic.ac.kr
- 2Department of Urology, College of Medicine, Kyungpook National University, Korea.
- 3Department of Urology, College of Medicine, Korea University, Korea.
- 4Department of Urology, College of Medicine, Dong-A University, Korea.
- 5Department of Urology, College of Medicine, Pusan National University, Korea.
- 6Department of Urology, College of Medicine, Seoul National University, Korea.
- 7Department of Urology, College of Medicine, Soonchunhyang University, Korea.
- 8Department of Urology, College of Medicine, Yonsei University, Korea.
- 9Department of Urology, College of Medicine, Wonkwang University, Korea.
- 10Department of Urology, College of Medicine, Ewha Womans University, Korea.
- 11Department of Urology, College of Medicine, Inje University, Korea.
- 12Department of Urology, College of Medicine, Chonnam National University, Korea.
- 13Department of Urology, College of Medicine, Chosun University, Korea.
- 14Department of Urology, College of Medicine, Chungbuk National University, Korea.
- 15Department of Urology, College of Medicine, Hanyang University, Korea.
Abstract
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PURPOSE: Worldwide data shows that there is an increasing resistance among urinary tract pathogens to the first-line antimicrobial agents used in domestic areas. The objective of this study was to obtain data on the susceptibility patterns of the pathogens responsible for acute uncomplicated cystitis to currently used antimicrobial agents.
MATERIALS AND METHODS
This study was carried out with the participation of fifteen hospitals in South Korea. A total of 239 isolates were obtained from female outpatients with acute uncomplicated cystitis. The antimicrobial susceptibilities to ampicillin, ampicillin/sulbactam, ciprofloxacin, gentamicin, trimethoprim/sulfamethoxazole(TMP/SMX) and tobramycin were determined by Vitek(R) antimicrobial susceptibility test systems.
RESULTS
The most prevalent causative organism was Escherichia coli(79.9%), followed by coagulase negative Staphylococcus(4.2%), and a combination of other species of Enterobacteriaceae(8.2%). The mean rates of susceptibility were 35.5, 45.0, 85.7, 81.5, 62.1 and 85.3% to ampicillin, ampicillin/sulbactam, ciprofloxacin, gentamicin, TMP/ SMX and tobramycin, respectively. No significant differences were detected in the resistance rates between the results from 4 regional groups.
CONCLUSIONS
The high prevalence of resistance to ampicillin, ampicillin/sulbactam, and TMP/SMX suggest these drugs would not provide adequate initial therapy, and therapies other than TMP/SMX may need to be considered. The relatively high prevalence of resistance to ciprofloxacin, compared with other countries, also requires on going surveillance to identify further changes among urinary tract isolates.
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