Korean J Urol.  1999 May;40(5):613-616.

The Effect of Desmopressin in Nocturia

• Lee DH
• Kim JC
• Suh HJ
• Kim HW
• Hwang TK

Abstract

PURPOSE: Nocturia results in sleep disturbance that may affect the quality of life during the day. We investigated the safety and efficacy of desmopressin in patients with nocturia without consideration of their underline diseases.
MATERIALS AND METHODS
30 patients who showed nocturia of 3 times or more per night were included in this study. All had failed to respond to treatment with regard to their underline disease and evening fluid restriction. Urinary specific gravity and osmolality, serum osmolality, BUN, Cr, Na, and K were monitored and voiding diary for 3 days was taken before and during treatment for 2 weeks. Meanwhile, patients whose nocturia were improved during treatment were asked whether symptom improvement continued or not after cessation.
RESULTS
In 23(76.7%) out of 30 patients, desmopressin caused a significant decrease in nocturia without changing daytime frequency, laboratory data and serious adverse effects. After cessation of desmopressin, this effect continued in 11 patients(36.7%).
CONCLUSIONS
Desmopressin seems to have a place in the treatment of nocturia, where more conventional therapies have failed.

Keyword

Nocturia; Desmopressin

MeSH Terms

Deamino Arginine Vasopressin*
Humans
Nocturia*
Osmolar Concentration
Quality of Life
Specific Gravity
Deamino Arginine Vasopressin