Korean J Urol.  2008 Oct;49(10):899-905. 10.4111/kju.2008.49.10.899.

Study on Persistent Nocturia after Treatment of Benign Prostatic Hyperplasia and Effectiveness of Desmopressin in Persistent Nocturia with Nocturnal Polyuria

• Jong JY
• Son JH

• KMID: 1204319
• DOI: http://doi.org/10.4111/kju.2008.49.10.899

Abstract

PURPOSE: We evaluated the differences in treatment outcomes between patients who complained of nocturia and patients who did not complain of nocturia after treatment with medication for benign prostatic hyperplasia(BPH) for >6 months. We also investigated the effectiveness of desmopressin on persistent nocturia after BPH medication.
MATERIALS AND METHODS
One hundred forty-nine patients with 3 or more episodes of nocturia, despite treatment with BPH medications, were enrolled. Patients were divided into two groups according to complaints or absence of complaints of persistent nocturia. We compared differences of the International Prostate Symptom Score(IPSS), quality of life(QoL), and nocturia between the two groups. Patients who complained of persistent nocturia were subdivided into the following three groups after administration of desmopressin(0.2mg/day) with cessation of BPH medication: group I, decreased nocturia(>2 episodes per night) with desmopressin only; group II, decreased nocturia with desmopressin, but the BPH symptoms are aggravated, and the previous medication was added; group III, no change of nocturia despite desmopressin. We analyzed the differences in each group.
RESULTS
Patients who complained of nocturia after BPH medication had a greater decrease in IPSS than those who did not complain of nocturia (p=0.047). Twenty percent(n=9) of the patients had decreased nocturia and were satisfied with desmopressin treatment, Twenty-four of the patients (53.3%) had decreased nocturia, but needed a combination with the previous BPH medication, while desmopressin was not effective in 26.7% (n=12) of the patients. The improvement of BPH after primary treatment was more evident in patients who experienced efficacy with desmopressin.
CONCLUSIONS
Desmopressin can be an effective treatment for persistent nocturia in patients with nocturnal polyuria components. The more improvement in BPH after primary treatment, the better the effects of desmopressin can be expected. We cannot overemphasize the importance of a voiding diary and analysis of nocturia.

Keyword

Benign prostatic hyperplasia; Nocturia; Desmopressin

Figure

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  Fig. 1. Progress of treatment for patients with persistent nocturia. BPH: benign prostatic hyperplasia, V.D: voiding diary, NPI: nocturnal polyuria index, NP: nocturnal polyuria, DDAVP: desmopressin acetate.

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  Fig. 2. Comparison of the changes in IPSS, QoL, and number of nocturia after primary BPH treatment between groups A and B. ∗: p＜0.05, IPSS: International Prostate Symptom Score, QoL: quality of life, BPH: benign prostatic hyperplasia.

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  Fig. 3. Treatment-related changes of nocturia. ∗: p＜0.05, BPH: benign prostatic hyperplasia, DDAVP: desmopressin acetate.

Reference

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