Korean J Psychopharmacol.  2006 Mar;17(2):212-218.

Association Study of the -36C>T Polymorphism in the Cholecystokinin Promoter Gene with the Diagnosis and the Response of Pharmacotherapy in Korean Patients with Panic Disorder

• Choi YH
• Kim W
• Bae JH
• Kim NY
• Chung YC
• Woo JM

Abstract

OBJECTIVE
This study aimed to test the possible association between cholecystokinin (CCK) promoter gene and panic disorder.
METHODS
267 patients with panic disorder and 82 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-based method.
RESULTS
Genotype and allele distribution of CCK promoter -36C>T polymorphism patients with panic disorder was not significantly different from those of the controls. In addition, after excluding panic disorder patients with major depressive disorder, we did not find out the association of CCK-36C>T with the panic disorder without comorbidities.
CONCLUSION
This study suggested that the CCK promoter -36C>T polymorphism may have not a potential role for susceptibility to panic disorder in the Korean population. Thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

Keyword

Panic disorder; Cholecystokinin; Polymorphism; Korean

MeSH Terms

Alleles
Cholecystokinin*
Comorbidity
Depressive Disorder, Major
Diagnosis*
Drug Therapy*
Genotype
Humans
Panic Disorder*
Panic*
Cholecystokinin