Korean J Psychopharmacol.  2003 Mar;14(1):63-66.

Efficacy of Clozapine on Schizophrenia with Polydipsia: Two Cases Experience

• Kim CE
• Park NJ
• Kang MH
• Bae JN

Abstract

Polydipsia occurs frequently in chronic schizophrenic patients, some of whom develop hyponatremia. Although the underlying pathophysiology of polydipsia among psychiatric patients, recent reports indicate that clozapine treatment improves polydipsia-hyponatremia in schizophrenia. Two schizophrenic patients with polydipsia, followed for more than two years, showed improvement on clozapine. Case 1 was a patient without history of hyponatremia who improved from polydipsia and psychosis. Case 2 was an inpatient with polydipsia and hyponatremia who showed improvement of polydipsia and did nor recur hyponatremia. The limited information provided by these case reports suggest the need for controlled studies of the clozapine effect on schizophrenic patients with polydipsia.

Keyword

Polydipsia; Hyponatremia; Schizophrenia; Clozapine

MeSH Terms

Clozapine*
Humans
Hyponatremia
Inpatients
Polydipsia*
Psychotic Disorders
Schizophrenia*
Clozapine