Korean J Psychopharmacol.  1997 Apr;8(1):79-89.

Relationship between Risperidone-Induced Therapeutic Response and Plasma Homovanillic Acid and 5-Hydroxyindoleacetic Acid Levels in Patients with Schizophrenia

• Kim CH
• Kim JW
• Lee HS
• Kim KH

Abstract

OBJECTIVES
This study was purposed to examine the changes of plasma homovanillic acid(HVA), 5-hydroxyindoleacetic acid(5-HIAA), and HVA/5-HIAA ratio during an 8-week risperidone trial and to investigate the relationship between the plasma monoamine metabolites and risperidone-induced treatment resposes. METHOD: Eighteen schizophrenic patients were treated for 8 weeks with risperidone. The psychopathology was assessed at baseline just before risperidone trial and then at 1st week, 2nd week, 4th week, and 8th week using the Positive and Negative Syndrome Scale(PANSS) and the Clinical Global Impression scale(CGI). The plasma HVA and 5-HIAA levels were measured using high performance liquid chromatography with electrochemical detection method.
RESULTS
39% of the patients treated with risperidone was categorized as responders, who showed at least a 20% decrease in PANSS total score at the end point of the study. At the end point of the 1st week, there was significant difference in the percent change of plasma HVA between responders(39% increment) and nonresponders(9% increment). But no significant differences in the percent change of plasma 5-HIAA and the percent change of plasma HVA/5-HIAA ratio between responders and nonresponders were observed.
CONCLUSION
These results suggest that the magnitude of the early increase of plasma HVA may be associated with risperidone-induced treatment response in schizophrenia.

Keyword

Schizophrenia; Risperidone; Plasma HVA; Plasma 5-HIAA; Plasma HVA/5-HIAA

MeSH Terms

Chromatography, Liquid
Homovanillic Acid*
Humans
Hydroxyindoleacetic Acid
Plasma*
Psychopathology
Risperidone
Schizophrenia*
Homovanillic Acid
Hydroxyindoleacetic Acid
Risperidone