Korean J Psychopharmacol.
2001 Sep;12(3):211-221.
A Multicenter Study on Effects of Nefazodone(Serzone TM) on Depression, Anxiety, Sleep, Sexual Functions, and Quality of Life in Patients with Depression
- Affiliations
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- 1Department of Psychiatry, Yonsei University, College of Medicine, Seoul. skmin518@yumc.yonsei.ac.kr
- 2Department of Psychiatry, Kyungpook University College of Medicine, Daegu.
- 3Department of Psychiatry, Korea University, College of Medicine, Seoul.
- 4Department of Psychiatry, Seoul National University, College of Medicine, Seoul.
- 5Department of Psychiatry, Chonnam University Medical School, Kwangju.
- 6Department of Biostatistics, Yonsei University, College of Medicine, Seoul.
- 7Department of Psychiatry, Inha University, College of Medicine, Inchon.
- 8Department of Psychiatry, Samsung Seoul Hospital, Sungkyunkwan University, College of Medicine, Seoul.
- 9Department of Psychiatry, Pusan University, College of Medicine, Pusan.
- 10Department of Psychiatry, Guri Hospital, Hanyang University, College of Medicine, Guri.
- 11Department of Psychiatry, Ahnsan Hospital, Korea University, College of Medicine, Ahnsan.
- 12Maryknoll Hospital, Pusan.
- 13Department of Psychiatry, Wonkwang University, College of Medicine, Iri.
- 14St. John of God Hospital, Kwangju.
- 15Department of Psychiatry, Choonchun Sungsim Hospital, Hallym University, College of Medicine, Choonchun.
- 16Department of Psychiatry, Kangdong Sungsim Hospital, Hallym University, College of Medicine, Seoul.
- 17Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul.
- 18Naju Psychiatry Hospital, Naju.
- 19Department of Psychiatry, Dankook University, College of Medicine, Chonahan.
- 20Department of Psychiatry, Chonbuk National University Medical School, Chonju.
- 21Department of Psychiatry, Ajou University, College of Medicine, Soowon.
- 22Department of Psychiatry, Chungbuk University, College of Medicine, Chungju.
- 23Department of Psychiatry, Chonahn Hospital, Soonchunhyang University, College of Medicine, Chonahn.
- 24Chwachon Bongseng Hospital, Pusan.
- 25Department of Psychiatry, Chungnam University, College of Medicine, Kwangju.
- 26Department of Psychiatry, Donga University, College of Medicine, Pusan.
- 27Department of Psychiatry, Soonchunhyang University, College of Medicine, Seoul.
- 28Department of Psychiatry, Seoul Chungang Hospital, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
Abstract
OBJECTIVE
The aim of this study is to determine effects of nefazodone on depression, anxiety, sleep and sexual function in depressive patients.
SUBJECTS AND METHODS
This is an open, non-comparative, multi-center study. Antidepressant and other clinical effects of nefazodone were evaluated in 230 patients of 26 centers, aged 14 years or more, who met DSM-IV criteria to major depressive disorder or dysthymic disorder and didn't have other psychiatric disorders and were physically healthy. The clinical efficacy was assessed at week 1, 2, 4 and 8 using Clinical Global Improvement (CGI), Hamilton Depression Scale (HAM-D), Beck Depression Inventory (BDI), State and Trait Anxiety Inventory-State Anxiety (STAI-SA). Other clinical effects were assessed with Weekly Sleep Questionnaire, Sexual Functioning Questionnaire and GHQ-QOL-12, a scale for quality of life. Adverse drug reactions were checked with a questionnaire. Post-treatment effects of drug were compared with pre-treatment baseline condition.
RESULTS
The response rates by Clincal Grobal Improvement and HAM-D after 8 weeks treatment were 62.4% and 75.2% respectively. Comparing to baseline, nefazodone was proved to have significantly higher antidepressant and antianxiety effects in depressive patients and it improved also sleep, sexual functions and quality of life. Both patients and physicians satisfied with the effects of drug. Adverse drug reactions were a few and not serious, and most of them disappeared as treatment continued.
CONCLUSION
These results suggest that not only nefazodone has antidepressant effects and antianxiety effects, but also it improves sleep disturbance, sexual dysfunction and the quality of life in depressive patients. Adverse drug reactions were a few and not serious.
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