Korean J Psychopharmacol.  2004 Mar;15(1):9-13.

Recent Advances in the Pharmacotherapy of Generalized Anxiety Disorder

  • 1Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
  • 2Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea.


Generalized anxiety disorder (GAD), that has been introduced into psychiatric nosology in DSM-III, is characterized by chronic worry that may persist for many years. Pharmacological treatment for GAD includes benzodiazepines, buspirone, and antidepressants. Benzodiazepine have commonly been used for treatment of acute anxiety disorders, but they are not ideal in the treatment of chronic generalized anxiety disorder (GAD). Buspirone appears to exert benefit primarily on psychic symptoms of anxiety, but the effect of buspirone is slower in onset, taking at least 2 weeks to become evident. Recently, new antidepressants has opened up a new area of investigation into pharmacotherapy of GAD, with a growing body of evidence supporting the role of therapies such as paroxetine and venlafaxine extended release. At present, some selective serotonin reuptake inhibitors such as paroxetine and venlafaxine are recommended for the best evidence-based approach in the long-term treatment of GAD.


GAD; Paroxetine; Venlafaxine
Full Text Links
  • KJP
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr