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A Case Report of Rare Adverse Events Associated with Venlafaxine Administration: Hypoglycemia and Lactic Acidosis

Özdemir S

We report the first case of hypoglycemia and lactic acidosis caused by the therapeutic doses of venlafaxine. A 19-year-old female patient had presyncope and she was taking venlafaxine 75 mg...
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Central Pontine Myelinolysis in a Normonatremic Patient with Depression

Liu YC, Yang YK, Chen PS, Chang WH

A 76-year-old male presented with a recurrent depressive episode, an unsteady gait and cognitive impairment. Extensive blood tests, including hemogram, biochemical tests, folic acid, vitamin B12, and thyroid hormone, showed...
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Paroxetine versus Venlafaxine and Escitalopram in Korean Patients with Major Depressive Disorder: A Randomized, Rater-blinded, Six-week Study

Woo YS, McIntyre R, Kim JB, Lee MS, Kim JM, Yim HW, Jun TY

OBJECTIVE: The purpose of this study was to compare the efficacy and safety of escitalopram, paroxetine and venlafaxine in Korean patients with major depressive disorder (MDD). METHODS: A total of 449...
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Dose Dependent Course of Hyperprolactinemic and Normoprolactinemic Galactorrhea Induced by Venlafaxine

Camkurt MA, Gülpamuk , Fındiklı E, Elve R

Venlafaxine is a serotonergic and noradrenergic reuptake inhibitor which is used for the treatment of depression. We report a case of galactorrhea in a patient with major depressive disorder after...
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Profiling of Proteins Regulated by Venlafaxine during Neural Differentiation of Human Cells

Doh MS, Han DM, Oh DH, Kim SH, Choi MR, Chai YG

OBJECTIVE: Antidepressants are known to positively influence several factors in patients with depressive disorders, resulting in increased neurogenesis and subsequent relief of depressive disorders. To study the effects of venlafaxine...
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Efficacy of Venlafaxine Hydrochloride Extended Release for the Treatment of Perimenopausal Depressive Women with Vasomotor Symptoms: Open-Label Observation Study

Kim MR, Lee JG, Baek JH, Kim YH

OBJECTIVE: During the transition to menopause, various symptoms including vasomotor symptoms and depressed mood lead to low quality of life. We investigated the effect of low-dose venlafaxine hydrochloride extended release...
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A Case of Venlafaxine-Induced Interstitial Lung Disease

Oh S, Cha SI, Kim H, Kim M, Choi SH, Seo H, Park TI

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed...
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Development of a LC-MS/MS for Quantification of Venlafaxine in Human Plasma and Application to Bioequivalence Study in healthy Korean Subjects

Kang HK, Kang MA, Kim HJ, Park YS, Kim SH, Kang JS

  • KMID: 2317857
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):35-42.
A simple, rapid and selective liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is developed and validated for quantification of venlafaxine in human plasma with simple liquid-liquid extraction step consisted...
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Venlafaxine-Induced Acute Toxic Hepatitis

Na KS, Hwang H, Kim SG, Lee SI, Jung HY

  • KMID: 2250138
  • Korean J Biol Psychiatry.
  • 2011 Aug;18(3):159-162.
Venlafaxine is among the most widely prescribed antidepressants. It is extensively metabolized to O-desmethylvenlafaxine via cytochrome P450 (CYP) 2D6. We report a case of acute toxic hepatitis resulting from venlafaxine...
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Uncontrolled Self-Medication with Venlafaxine in a Patient with Major Depressive Disorder

Song JH, Yu BH, Lee D, Yoon SC, Jeon HJ

  • KMID: 2315933
  • Psychiatry Investig.
  • 2011 Mar;8(1):74-76.
Antidepressants are known to have no significant ability to cause addiction. However, a recent study showed many individuals with mood disorders self-medicated with antidepressants to relieve symptoms. We report here...
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The Effects of Venlafaxine and Dexamethasone on the Expression of HSP70 in Rat C6 Glioma Cells

Yu J, Roh S, Lee JS, Yang BH, Choi MR, Chai YG, Kim SH

  • KMID: 2315864
  • Psychiatry Investig.
  • 2010 Mar;7(1):43-48.
OBJECTIVE: The present study aimed to determine the intracellular action of the antidepressant, venlafaxine, in C6 glioma cells using heat shock protein 70 (HSP70) immunocytochemistry and HSP70 Western blots; HSP70...
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A Case Report of Hyponatremia Associated with Venlafaxine HCL in an Elderly Patient

You JI, Choi YM

  • KMID: 2287440
  • Korean J Psychopharmacol.
  • 2008 Jan;19(1):53-57.
Recent studies have indicated that hyponatremia can be associated with antidepressants, and venlafaxine is a widely used serotonin norepinephrine reuptake inhibitor (SNRI) that has been reported to induce this electrolyte...
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Effects of Venlafaxine ER on Blood Pressure during the Acute Treatment of Major Depressive Patients

Seo HJ, Suh JW, Jung YE, Kim SB, Chae JH, Jun TY, Kim KS, Bahk WM

  • KMID: 2287439
  • Korean J Psychopharmacol.
  • 2008 Jan;19(1):46-52.
OBJECTIVE: Venlafaxine is an antidepressant with a dual action of blocking reuptake of both serotonin and norepinephrine at therapeutic dose like some tricyclic antidepressants. However it may share the relative...
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Maintenance Period of Venlafaxine ER Treatment in Patients Having Major Depressive Disorder with Somatic Symptoms

Seo HJ, Woo YS, Chae JH, Jun TY, Bahk WM

  • KMID: 2287035
  • Korean J Psychopharmacol.
  • 2007 Sep;18(5):329-337.
OBJECTIVES: Medically unexplained physical symptoms comprised the predominant complaints of patients with depression in clinical settings. Previously, tricyclic antidepressants, which inhibit both presynaptic reuptake of serotonin and norepinephrine, had been...
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Vaginal Bleeding Associated with Venlafaxine Add-On Therapy: A Case Report

Jon DI

  • KMID: 2287246
  • Korean J Psychopharmacol.
  • 2006 Mar;17(2):238-240.
Venlafaxine is often considered to be safer than established antidepressants except the risk of hypertension. In terms of vaginal bleeding associated with venlafaxine, only one case has been reported. The...
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The Effectiveness of 6-Month Treatment with Venlafaxine Extended Release in Generalized Anxiety Disorder: Prospective, Multi-Center, Open-Labeled Trial

Park JE, Chae JH, Lee SH, Ryu SG, Kim CH, Oh KS, Kim YR, Yu BH

  • KMID: 2287262
  • Korean J Psychopharmacol.
  • 2006 Jan;17(1):50-59.
OBJECTIVE: We aimed to examine the efficacy and the safety of venlafaxine extended release (venlafaxine-XR), and its effect on the quality of life in patients with generalized anxiety disorder. METHODS:...
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Effects of Venlafaxine and Dexamethasone Treatment on HSP70 Expression in Rat C6 Glioma Cells

Yu JH, Lee JS, Yang BH, Choi MR, Chai YG, Kim SH, Roh SW, Oh DY, Choi IG

  • KMID: 2299955
  • Korean J Biol Psychiatry.
  • 2005 Nov;12(2):136-142.
OBJECT: The intracellular action of the antidepressant, venlafaxine, was studied in C6-gliomas using heat shock protein 70(HSP70) immunocytochemistry and HSP70 Western blots because HSP70 is associated with stress and depression. METHODS:...
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Recent Advances in the Pharmacotherapy of Generalized Anxiety Disorder

Kim CH

  • KMID: 2286869
  • Korean J Psychopharmacol.
  • 2004 Mar;15(1):9-13.
Generalized anxiety disorder (GAD), that has been introduced into psychiatric nosology in DSM-III, is characterized by chronic worry that may persist for many years. Pharmacological treatment for GAD includes benzodiazepines,...
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The Acute Pharmacodynamic Effects of Venlafaxine and Mirtazapine on Psychomotor Performance, Motor Activity, and Daytime Sleepiness

Yoon JS, Yoon BH, Cha HC, Kim MK

  • KMID: 2286922
  • Korean J Psychopharmacol.
  • 2001 Sep;12(3):242-250.
OBJECTIVE: For the optimal use of antidepressants, it is important to consider the behavioral effects of drugs affecting the real lives of depressed patients, as there is little difference in...
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The Effects of Selective Norepinephrine Reuptake Inhibitors (SNRIs) on the Urethral Pressure

Bae JH, Moon DG, Lee JG

  • KMID: 2292322
  • Korean J Urol.
  • 2001 Jun;42(6):657-662.
PURPOSE: This study was performed to identify the effects of selective norepinephrine reuptake inhibitor (SNRI, venlafaxine) on the urethral perfusion pressure (UPP) and also to assess its therapeutic potentials for...
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