Gut Liver.  2009 Dec;3(4):343-348.

A Case of Hepatocellular Carcinoma with Pulmonary Metastases Treated Successfully with a Combination of Repeated Hepatic Arterial Infusion Epirubicin and Cisplatin Chemotherapy and Systemic Low-Dose Infusion of 5-Fluorouracil

• Oh YJ
• Park YM
• Kim BH
• Kim MJ
• Cho JH
• Cha CW
• Park SJ
• Yeon JW

Abstract

We report a case of hepatocellular carcinoma (HCC) with pulmonary metastases treated with repeated hepatic arterial infusion chemotherapy (HAIC) comprising epirubicin and cisplatin, and systemic infusion of 5-fluorouracil (a modified EC/F protocol), which led to complete remission. A 49-year-old man with compensated liver cirrhosis experienced intrahepatic recurrence of HCC with extensive lung metastases. The modified EC/F therapeutic protocol, which was applied at the tenth cycle every 4-5 weeks, resulted in disappearance of the pulmonary metastases and normalization of serum alpha-fetoprotein levels. A single small HCC lesion was found in the left lobe of the liver 13 months after the final chemotherapy session. HAIC with the same regimen was conducted again, followed by percutaneous intratumoral chemoinjection therapy with 5-fluorouracil and interferon-gamma. Thereafter, there was no evidence of recurrence in either the liver or the lung, as evidenced by image analysis and expression of tumor markers. The disease-free intervals for the liver and lung were 41 and 54 months, respectively.

Keyword

Carcinoma, Hepatocellular; Lung metastasis; Hepatic arterial infusion chemotherapy; Drug therapy

MeSH Terms

alpha-Fetoproteins
Carcinoma, Hepatocellular
Cisplatin
Epirubicin
Fluorouracil
Humans
Interferon-gamma
Liver
Liver Cirrhosis
Lung
Middle Aged
Neoplasm Metastasis
Recurrence
Biomarkers, Tumor
Cisplatin
Epirubicin
Fluorouracil
Interferon-gamma
alpha-Fetoproteins