Diabetes Metab J.  2011 Aug;35(4):390-396. 10.4093/dmj.2011.35.4.390.

Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients

• Chung JO
• Cho DH
• Chung DJ
• Chung MY

• KMID: 2281646
• DOI: http://doi.org/10.4093/dmj.2011.35.4.390

Abstract

BACKGROUND
Diabetes mellitus is a major independent risk factor for cardiovascular disease (CVD), but high cardiovascular risk in diabetes mellitus patients is not completely explained by clustering traditional risk factors. Recently, associations between diabetic polyneuropathy (DPN) and macrovasculopathy have been suggested. We aimed to assess associations between DPN and cardiovascular complications in type 2 diabetic patients.
METHODS
Microvascular and cardiovascular complications were evaluated in 1,041 type 2 diabetic patients.
RESULTS
In patients with DPN, the age, prevalence of hypertension, diabetes duration, systolic blood pressure, pulse pressure, and hemoglobin glycation (HbA1c) levels were significantly higher, while the high density lipoprotein cholesterol (HDL-C) levels were lower than in those without DPN. The prevalence of CVD was higher in patients with DPN. In multivariate analysis, DPN was independently associated with CVD (odds ratio, 1.801; 95% confidence interval, 1.009 to 3.214).
CONCLUSION
Our results showed that DPN was associated with a high prevalence of cardiovascular disease in type 2 diabetic patients, but further studies are needed to investigate the causative nature of associations between DPN and CVD.

Keyword

Cardiovascular diseases; Diabetes mellitus, type 2; Diabetic neuropathies

MeSH Terms

Blood Pressure
Cardiovascular Diseases
Cholesterol
Cholesterol, HDL
Diabetes Mellitus
Diabetes Mellitus, Type 2
Diabetic Neuropathies
Hemoglobins
Humans
Hypertension
Lipoproteins
Multivariate Analysis
NAD
Prevalence
Risk Factors
Cholesterol
Cholesterol, HDL
Hemoglobins
Lipoproteins
NAD

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