Korean J Perinatol.  2014 Dec;25(4):292-296. 10.14734/kjp.2014.25.4.292.

A Case Report of Heterokaryotypic Monochorionic Twin Pregnancy with Discordant for Turner Syndrome

  • 1Department of Obstetrics and Gynecology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea. kksdoc25@naver.com


Monochorionic twins with discordant karyotypes are rare and mostly caused by post-zygotic mitotic nondisjunction. A 32 year old nulliparous woman at 11 weeks of gestation with spontaneous twin pregnancy was referred to our hospital. An amniocentesis was performed in both amniotic sacs at 15 weeks of pregnancy. One fetus in monochorionic twin pregnancy was diagnosed with Turner syndrome with cystic hygroma, and the other fetus was normal. Because of high mortality rate in abnormal fetuses, the umbilical cord coagulation was performed using radiofrequency ablation to prevent the damage of co-twin that may be caused by the demise of one fetus. After delivery, chorionicity of placenta was ascertained by pathologic exam. Postnatal findings of physical exam, abdominal and brain sonography were normal in the surviving neonate.


Monochorionic twin; Discordant karyotype; Turner syndrome; Radiofrequency ablation

MeSH Terms

Catheter Ablation
Infant, Newborn
Lymphangioma, Cystic
Pregnancy, Twin*
Turner Syndrome*
Umbilical Cord


  • Fig. 1. (A) Monochorionic diamniotic twin at 11 weeks of gestation. (B) Cystic hygroma at 17 weeks of gestation.

  • Fig. 2. (A) A gross photograph of monochorionic diamniotic placenta shows the necrotic portion (arrow) of the abnormal twin. (B) Pathologic finding of interfetal amniotic membrane (arrow) shows the absence of an intervening chorionic layer (H&E, x200).


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