Korean J Perinatol.  2010 Dec;21(4):338-346.

Twin-to-Twin Transfusion Syndrome: Diagnosis and Managements

Affiliations
  • 1Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. sabi0515@hanmail.net

Abstract

Twin-to-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies, characterized by the development of unbalanced chronic blood transfer from one twin, defined as donor twin, to the other, defined as recipient, through placental anastomoses. The incidence of TTTS in monochorionic diamniotic gestations is approximately 10% to 20%. The natural history of severe TTTS is well established with mortality approaching 80% to 100% if left untreated, especially when it presents at less than 20 weeks' gestation. This review presents overview of what is known about the pathophysiology and the diagnosis of TTTS, the markers for early detection of TTTS, treatment options available for TTTS, and complications of treatment for TTTS.

Keyword

Twin-to-twin transfusion syndrome (TTTS); Monochorionic twins

MeSH Terms

Female
Fetofetal Transfusion
Humans
Incidence
Natural History
Pregnancy
Pregnancy, Twin
Tissue Donors
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