Korean J Pediatr.  2006 Nov;49(11):1223-1226. 10.3345/kjp.2006.49.11.1223.

Pyridoxine responsive sideroblastic anemia in a boy with mitral valve prolapse

• Sung JS
• Kim KH
• Han DG
• Kim MJ
• Cho YK
• Chung HY
• Baek HJ
• Ma JS
• Kook H
• Hwang TJ

• KMID: 2280071
• DOI: http://doi.org/10.3345/kjp.2006.49.11.1223

Abstract

Sideroblastic anemia is a rare, heterogeneous group of disorders characterized by hyperferremia, microcytic hypochromic anemia, and bone marrow erythroid hyperplasia with the presence of numerous ringed sideroblasts. We describe herewith the case of a rare coincidence of sideroblastic anemia and mitral valve prolapse with resultant regurgitation in a 2-year-old boy. In addition to the inherent propensity for the development of cardiac dysfunction in sideroblastic anemia due to transfusion-associated myocardial iron overload and chronic anemia, a coincidence of MVP will further increase the likelihood of the morbidity or mortality of th patient. in this patient. After response to pyridoxine, the patient remains in good condition with stable hemoglobin levels.

Keyword

Sideroblastic anemia; Pyridoxine; Mitral valve prolapse

MeSH Terms

Anemia
Anemia, Hypochromic
Anemia, Sideroblastic*
Bone Marrow
Child, Preschool
Humans
Hyperplasia
Iron Overload
Male*
Mitral Valve Prolapse*
Mitral Valve*
Mortality
Pyridoxine*
Pyridoxine