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Role of redox iron towards an increase in mortality among patients: a systemic review and meta-analysis

Sharma S

An increase in biochemical concentrations of non-transferrin bound iron (NTBI) within the patients with an increase in serum iron concentration was evaluated with the following objectives: (a) Iron overloading diseases/conditions...
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Molecular perspective of iron uptake, related diseases, and treatments

Shokrgozar N, Golafshan

Iron deficiency anemia and anemia of chronic disorders are the most common types of anemia. Disorders of iron metabolism lead to different clinical scenarios such as iron deficiency anemia, iron...
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Deferiprone Related Arthropathy in 11-Year-Old Boy with Hereditary Spherocytosis

Seo YK, Han JK, Suh WS, Park KB

Regular transfusion therapy in children with intractable hematologic disorder results in hemosiderosis. It causes several organ damages such as liver, heart, and endocrine system and increases risk of infection. Thus,...
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Transfusional Iron Overload and Choroid Plexus Hemosiderosis in a Pediatric Patient: Brain Magnetic Resonance Imaging Findings

Kim MS, Lee HY, Lim MK, Kang YH, Kim JH, Lee KH

Hemosiderosis is characterized by the deposition of excess iron in body tissues. The choroid plexus is an important part of the central nervous system that can be the primary site...
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Causes of Hyperferritinemia and Red Blood Cell Transfusion

Kim MS, Kim SH

BACKGROUND: Ferritin is used to detect iron overload in patients with chronic red blood cell transfusions. Although ferritin reflects the amount of iron storage in the body, it may increase...
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Relationship between liver iron concentration determined by R2-MRI, serum ferritin, and liver enzymes in patients with thalassemia intermedia

Al-Momen H, Jasim SK, Hassan QA, Ali HH

BACKGROUND: Iron overload is a risk factor affecting all patients with thalassemia intermedia (TI). We aimed to determine whether there is a relationship of serum ferritin (SF) and alanine aminotransferase...
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Effect of iron overload with ascorbic acid on experimental colon carcinogenesis in mice

Ahn TH, Kim SJ, Jeong JH, Nam SY, Yun YW, Lee BJ

Excessive iron can promote the production of free radicals, thereby leading to harmful effects on cancer and aging. Ascorbic acid is not only an antioxidant but also a co-factor of...
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Treatment and Management of Late Complications in Hereditary Hemolytic Anemia

Chueh HW

Hereditary hemolytic anemia is a very heterogeneous disorder in which abnormalities of red blood cell structural protein, globin protein, or enzyme defect lead to shortened life span. There has been...
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Subclinical left ventricular dysfunction in children after hematopoietic stem cell transplantation for severe aplastic anemia: a case control study using speckle tracking echocardiography

Kim BJ, Moon KP, Yoon JH, Lee EJ, Lee JY, Kim SK, Lee JW, Chung NG, Cho B, Kim HK

PURPOSE: Severe aplastic anemia (SAA), a fatal disease, requires multiple transfusion, immunosuppressive therapy, and finally, hematopoietic stem cell transplantation (HSCT) as the definitive treatment. We hypothesized that iron overloading associated...
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Survey of experts on therapeutic policies and proposals for the optimal timing for allogeneic peripheral blood stem cell transplantation in transfusion-dependent patients with myelodysplastic syndrome-refractory anemia

Sohn SK, Moon JH, Lee YJ, Park SW, Kim JY

BACKGROUND: Most hypomethylating agent (HMA) responders with myelodysplastic syndrome (MDS) eventually need allogeneic stem cell transplantation (SCT) because they often acquire resistance to HMAs within two years of treatment. Considering...
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Associations between Lifestyle Factors and Iron Overload in Korean Adults

Kim H, Shin C, Baik I

It has been suggested that iron overload, which indicates the accumulation of iron, generates cellular reactive oxygens and causes peroxide damages to the body. Such oxidative stresses, in a broader...
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Hepatic veno-occlusive disease may develop in secondary iron overloaded mice after allogeneic hematopoietic stem cell transplantation with total body irradiation

Yeom MY, Kim YJ, Chung NG, Lee JW, Jang PS, Cho B, Kye CS, Jeong DC

BACKGROUND: The outcome of hematopoietic stem cell transplantation (HSCT) is poor in patients with secondary iron overload (SIO). We evaluated the relationship between SIO and veno-occlusive disease (VOD) in an...
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The Iron Status of Very Low Birth Weight Infants Receiving Multiple Erythrocyte Transfusions during Hospitalization in the Neonatal Intensive Care Unit

Park SH, Kim HM

PURPOSE: We investigated the iron status of very low birth weight infants receiving multiple erythrocyte transfusions during hospitalization in the neonatal intensive care unit (NICU). METHODS: We enrolled 46 very low...
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Optimal method for early detection of cardiac disorders in thalassemia major patients: magnetic resonance imaging or echocardiography?

Moussavi F, Ghasabeh M, Roodpeyma , Alavi S, Shakiba M, Gheiratmand R, Omidghaemi M

BACKGROUND: Heart failure resulting from myocardial iron deposition is the most important cause of death in beta-thalassemia major (TM) patients. Cardiac T2*magnetic resonance imaging (MRI), echocardiography, and serum ferritin level...
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Noninvasive Assessment of Hepatic Fibrosis in Patients with Chronic Hepatitis B Viral Infection Using Magnetic Resonance Elastography

Lee JE, Lee JM, Lee KB, Yoon JH, Shin CI, Han JK, Choi BI

OBJECTIVE: To evaluate the diagnostic performance of magnetic resonance elastography (MRE) for staging hepatic fibrosis in patients with chronic hepatitis B virus (HBV) infection. MATERIALS AND METHODS: Patients with chronic HBV...
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Efficacy and safety of combined oral iron chelation therapy with deferasirox and deferiprone in a patient with beta-thalassemia major and persistent iron overload

Alavi S, Sadeghi E, Ashenagar

No abstract available.
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Regulation of Iron and Its Significance in Obesity and Complications

Chan YK, Sung HK, Sweeney G

Iron is an essential micronutrient with important roles in many critical physiological processes, especially as a structural component of hemoglobin responsible for oxygen transport. Iron homeostasis is tightly regulated, yet...
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Role of hepcidin in the pathophysiology and diagnosis of anemia

D'Angelo G

This review summarizes the central role of hepcidin in the iron homeostasis mechanism, the molecular mechanism that can alter hepcidin expression, the relationship between hepcidin and erythropoiesis, and the pathogenetic...
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Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload

Jang JH, Lee JH, Yoon SS, Jo DY, Kim HJ, Chung J, Lee JW

Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an...
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Iron Overload during Follow-up after Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Patients with High-Risk Neuroblastoma

Bae SJ, Kang C, Sung KW, Chueh HW, Son MH, Lee SH, Yoo KH, Koo HH

Multiple RBC transfusions inevitably lead to a state of iron overload before and after high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT). Nonetheless, iron status during post-SCT follow-up remains unknown....
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