Clin Pediatr Hematol Oncol.  2014 Oct;21(2):135-139. 10.0000/cpho.2014.21.2.135.

A Case of Childhood Paroxysmal Cold Hemoglobinuria Related with Suspicious Chlamydia Infection

Affiliations
  • 1Center for Pediatric Oncology, Department of Laboratory Medicine, National Cancer Center, Goyang, Korea. hjpark@ncc.re.kr
  • 2Center for Diagnostic Oncology, Department of Laboratory Medicine, National Cancer Center, Goyang, Korea.
  • 3Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.

Abstract

Paroxysmal cold hemoglobinuria (PCH) is a rare diagnosis of acquired hemolytic anemia in children, which is caused by a specific cold antibody named Donath-Landsteiner hemolysin. Although various bacteria or viruses were reported as triggering factor of PCH, childhood PCH related to Chlamydia pneumoniae infection is uncommon. The authors report a case of childhood PCH which is related with suspicious Chlamydia pneumoniae infection, with a review of pertinent literature.

Keyword

Paroxysmal cold hemoglobinuria; Hemolytic anemia; Chlamydia pneumoniae; Childhood

MeSH Terms

Anemia, Hemolytic
Bacteria
Child
Chlamydia Infections*
Chlamydophila pneumoniae
Diagnosis
Hemoglobinuria, Paroxysmal*
Humans
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