Korean J Pathol.
2011 Feb;45(1):111-114.
Sclerosing Angiomatoid Nodular Transformation (SANT) in Spleen: A Case Report
- Affiliations
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- 1Department of Pathology, Chungnam National University College of Medicine, Daejeon, Korea. jinmank@cnu.ac.kr
- 2Department of Surgery, Chungnam National University College of Medicine, Daejeon, Korea.
- 3Cancer Research Institute, Daejeon Regional Cancer Center, and Infection Signaling Network Research Center, Chungnam National University College of Medicine, Daejeon, Korea.
Abstract
- Sclerosing angiomatoid nodular transformation (SANT) of spleen is a rare inflammatory tumor-like vascular lesion composed of angiomatoid nodules in a fibrosclerotic background. We report herein on a case of SANT in the spleen with its pathologic features, and review the related literature. A 50-year-old woman presented with mild left upper quadrant discomfort and tenderness and she showed a 6 cm-sized solitary splenic mass on computed tomography. She underwent laparoscopic splenectomy. Grossly, the spleen showed a well circumscribed round-shaped solid mass with multinodular hemorrhagic surfaces. Microscopically, the mass consisted of multiple angiomatoid nodules surrounded by collagen bundles with fibroblasts and a lymphoplasma cell infiltration. Immunohistochemically, the cells of the angiomatoid nodules were positive for CD31, CD30, CD34, alpha-smooth muscle actin, and VWF-VIII, but they were negative for CD8, anaplastic lymphoma kinase protein, and D2-40. The patient has been under close follow-up without recurrence.
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