Korean J Pathol.  2014 Jun;48(3):241-247.

A Case of Metastatic Angiosarcoma Diagnosed by Liquid-Based Preparation: Peculiar Cytoplasmic Changes

• Jung MJ
• Kim YO

Abstract

Angiosarcoma with predominantly epithelioid features is a rare soft tissue neoplasm and the interpretation of its cytopathologic findings may be difficult. We report a case of metastatic angiosarcoma with predominantly epithelioid features diagnosed by liquid-based cytology. The cytopathologic findings in this case differed from those of the conventional preparation and we found a clean background, no hyperchromatic nuclei and several cytoplasmic changes, including intracytoplasmic vacuoles with peculiar shapes, juxtanuclear condensation and perinuclear clearing. Identification of these changes using liquid-based cytology supplemented with immunochemistry may be helpful in reaching a correct cytopathologic diagnosis.

Keyword

Hemangiosarcoma; Cytodiagnosis; Cytologic techniques; Diagnosis; Differential; Liquid based preparation

MeSH Terms

Cytodiagnosis
Cytoplasm*
Diagnosis
Hemangiosarcoma*
Immunochemistry
Soft Tissue Neoplasms
Vacuoles