Korean J Otorhinolaryngol-Head Neck Surg.  2012 Jun;55(6):373-377. 10.3342/kjorl-hns.2012.55.6.373.

A Case of Asymptomatic Multiple Endocrine Neoplasia Type 1 Detected Incidentally on Health Screening

• Cho PS
• Park H
• Lee GH
• Lee MC

• KMID: 2277363
• DOI: http://doi.org/10.3342/kjorl-hns.2012.55.6.373

Abstract

Multiple endocrine neoplasia type 1 (MEN 1) is characterized by the coexistence of primary hyperparathyroidism, enteropancreatic tumors, and anterior pituitary adenoma. Also adrenal adenoma, lipoma, carcinoid tumors could exist simultaneously on the atypical clinical course of MEN 1. Among these diseases, primary hyperparathyroidism is the most common manisfestation of MEN 1 syndrome. However, it sometimes presents no clinical symptoms and is incidentally detected on medical checkup. A 48-year-old woman, while undergoing a regular medical check-up, was diagnosed with primary hyperparathyroidism. Further studies showed concurrence of pancreatic tumor and adrenal tumor, but there was no pituitary lesion. The patient underwent parathyroidectomy with auto-implantation of parathyroid tissue, pylorus preserving pancreatico-duodenectomy and partial adrenalectomy. The pathological test confirmed it to be parathyroid hyperplasia, well-differentiated pancreatic endocrine carcinoma and adrenal cortical adenoma. We report this atypical and asymptomatic case of MEN 1 with a review of the relevant literature.

Keyword

Multiple endocrine neoplasia type 1; Hyperparathyroidism; Parathyroid hyperplasia; Parathyroidectomy

MeSH Terms

Adenoma
Adrenalectomy
Adrenocortical Adenoma
Carcinoid Tumor
Female
Humans
Hyperparathyroidism
Hyperparathyroidism, Primary
Hyperplasia
Lipoma
Mass Screening
Middle Aged
Multiple Endocrine Neoplasia
Multiple Endocrine Neoplasia Type 1
Parathyroidectomy
Pituitary Neoplasms
Pylorus