Korean J Otolaryngol-Head Neck Surg.  2004 Jun;47(6):587-589.

A Case of Adenoid Cystic Carcinoma Ex Pleomorphic Adenoma of Submandibular Gland

Affiliations
  • 1Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Seoul, Korea.

Abstract

Carcinoma ex pleomorphic adenoma is a rare neoplasm of the salivary gland. This lesion occurs when a malignant tumor arises in the epithelial component of a pleomorphic adenoma. The patient was a 35-year-old male with ovoid shaped and protruding submandibular mass that has been present for 3 weeks. The initial radiologic diagnosis was suspicious of malignancy and the cytologic finding by fine needle aspiration biopsy showed highly malignant cells. After submandibular gland extirpation and supraomohyoid neck dissection, the histologic examination revealed that tumor was composed partly of a benign pleomorphic adenoma and partly of an adenoid cystic carcinoma component with areas of calcification, capsular invasion, and perineural invasion. The adenoid cystic carcinoma component showed a cribriform pattern, also known as "Swiss cheese appearance". We additionally did postoperative radiotherapy for 7 weeks. We present a rare case of carcinoma ex pleomorphic adenoma with adenoid cystic carcinoma in the submandibular gland.

Keyword

Pleomorphic adenoma; Adenoid cystic carcinoma; Submandibular gland
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