Korean J Otorhinolaryngol-Head Neck Surg.  2016 May;59(5):388-391. 10.3342/kjorl-hns.2016.59.5.388.

A Case of Adenosquamous Carcinoma Ex Pleomorphic Adenoma of Submandibular Gland

  • 1Department of Otorhinolaryngology-Head & Neck Surgery, Chungbuk National University College of Medicine, Cheongju, Korea. dwlee@chungbuk.ac.kr


We experienced a case of carcinoma ex pleomorphic adenoma arising in the submandibular gland of a 47-year-old male patient. The patient underwent submandibular gland ressection and supraomohyoid neck dissection. Histologic examination revealed that the malignant component of carcinoma ex pleomorphic adenoma was adenosquamous carcinoma. The patient refused postoperative radiation therapy and tumor recurred at the neck and lung about 18 month later. Modified radical neck dissection was carried out, and additional postoperative radiotherapy and palliative chemotherapy were initiated. To the best of our knowledge, this is the first case of carcinoma ex pleomorphic adenoma, of which the malignant component is adenosquamous carcinoma in the submandibular gland. Therefore the authors report this rare case with a literature review.


Adenosquamous carcinoma; Carcinoma ex pleomorphic adenoma; Submandibular gland
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