Korean J Otolaryngol-Head Neck Surg.  2004 Jan;47(1):52-55.

The Expression of p53 and PCNA in Patients with Locally Recurrent Laryngeal Cancer after Radiotherapy

• Lee BJ
• Wang SG
• Lee JC
• Yoon BN
• Goh EK
• Park DY
• Jeong HJ

Abstract

BACKGROUND AND OBJECTIVES
The biologic changes in recurrent laryngeal cancer following radiotherapy are not fully understood. The authors investigated the expression of p53 and proliferating cell nuclear antigen (PCNA) in patients with locally recurrent laryngeal cancer after radiotherapy. MATERIALS AND METHODS: The authors investigated the expression of p53 and PCNA by immunohistochemical stain in 15 patients with recurrent laryngeal cancer after radiotherapy. RESULTS: The expression of p53 protein was significantly different between laryngeal cancer before radiotherapy (4/15, 26.7%) and recurrent laryngeal cancer after radiotherapy (8/15, 53.3%) (p<0.05). Also, PCNA index was significantly different between laryngeal cancer before radiotherapy (mean, 11.9%) and recurrent laryngeal cancer after radiotherapy (mean, 18.0%) (p<0.05). CONCLUSION: The expressions of p53 protein and PCNA were increased more in the recurrent laryngeal cancer after radiotherapy than in the laryngeal cancer before radiotherapy. Recurrent laryngeal cancers changed to biologically aggressive cancer after following radiation therapy.

Keyword

Laryngeal neoplasms; Genes, p53; Proliferating cell nuclear antigen; Radiotherapy

MeSH Terms

Genes, p53
Humans
Laryngeal Neoplasms*
Proliferating Cell Nuclear Antigen*
Radiotherapy*
Proliferating Cell Nuclear Antigen