- Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway
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Liang Y, Wang S, Liu J
- KMID: 2450113
- J Breast Cancer.
- 2019 Jun;22(2):172-184.
- doi: 10.4048/jbc.2019.22.e21
PURPOSE: Tumor protein p53-regulated apoptosis-inducing protein 1 (TP53AIP1) functions in various cancers. We studied the effect and molecular mechanism of TP53AIP1 in breast cancer. METHODS: The degree of correlation between TP53AIP1... -
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- Expression of p63 and its association with cell proliferation at different stages of murine hair follicle cycle
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Lee BW, Oh JW, Seo M, Hwang JS, Yoon B
- KMID: 2436121
- J Biomed Transl Res.
- 2018 Mar;19(1):10-15.
- doi: 10.12729/jbtr.2018.19.1.010
In the present study, we investigated the expression patterns of p63, a member of the p53 gene family, in hair follicle cells at different stages of the hair cycle and... -
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- Development of Urinary Bladder Pre-Neoplasia by Schistosoma haematobium Eggs and Chemical Carcinogen in Mice
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Chala B, Choi MH, Moon KC, Kim HS, Kwak C, Hong ST
- KMID: 2374799
- Korean J Parasitol.
- 2017 Feb;55(1):21-29.
- doi: 10.3347/kjp.2017.55.1.21
Schistosoma haematobium is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting S. haematobium eggs into the bladder wall and introduction... -
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- The Evaluation of p53 Polymorphism at Codon 72 and Association With Breast Cancer in Iran: A Systematic Review and Meta-analysis
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Soleimani , Rahmani Y, Farshchian N, Delpisheh , Khassi K, Shahmohammadi A, Amirifard
- KMID: 2367567
- J Cancer Prev.
- 2016 Dec;21(4):288-293.
- doi: 10.15430/JCP.2016.21.4.288
BACKGROUND: Breast cancer is the most common cancer among women in Iran and the world. Multiple environmental factors and genetic variations such as genetic polymorphisms are of its main causes.... -
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- Cryopreservation of Human Wharton's Jelly-derived Mesenchymal Stem Cells Following Controlled Rate Freezing Protocol Using Different Cryoprotectants; A Comparative Study
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Shivakumar SB, Bharti D, Jang SJ, Hwang SC, Park JK, Shin JK, Byun JH, Park BW, Rho GJ
- KMID: 2380810
- Int J Stem Cells.
- 2015 Nov;8(2):155-169.
- doi: 10.15283/ijsc.2015.8.2.155
OBJECTIVES: To compare the effect of three different cryoprotectants on basic stem cell characteristics for the possibility of using well defined, dimethyl sulfoxide (DMSO) and serum free freezing solutions to... -
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- Osteosarcoma with Adenocarcinoma of Lung in Li-Fraumeni Syndrome: A Case Report
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Oh CS, Lee JH, Jung ST, Na BR
- KMID: 1799901
- J Korean Bone Joint Tumor Soc.
- 2014 Dec;20(2):99-103.
- doi: 10.5292/jkbjts.2014.20.2.99
Li-Fraumeni syndrome (LFS) is an autosomal dominant hereditary disorder characterised by a variety of different tumor types in children and young adults. That contains with a germline mutation in the... -
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- p53 Expression in a Malignant Mesothelioma Patient during Seven-Year Follow-up
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Koo SM, Uh ST, Kim DW, Kim KU, Kim YK
- KMID: 2320518
- Tuberc Respir Dis.
- 2014 Jun;76(6):284-288.
Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies.... -
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- Patterns and Biologic Features of p53 Mutation Types in Korean Breast Cancer Patients
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Kim HW, Lee HM, Hwang SH, Ahn SG, Lee KA, Jeong J
- KMID: 2353077
- J Breast Cancer.
- 2014 Mar;17(1):1-7.
PURPOSE: The p53 gene is one of the most frequently mutated genes in breast cancer. We investigated the patterns and biologic features of p53 gene mutation and evaluated their clinical... -
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- Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors
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Kim JH, Choi KY, Lee DJ, Rho YS, Jo SJ
- KMID: 2278408
- Clin Exp Otorhinolaryngol.
- 2014 Mar;7(1):53-58.
OBJECTIVES: To evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors. METHODS: Eighty thyroid tumor cases... -
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- Characteristics of hematologic malignancies with coexisting t(9;22) and inv(16) chromosomal abnormalities
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Han E, Lee H, Kim M, Kim Y, Han K, Lee SE, Kim HJ, Kim DW
- KMID: 2172819
- Blood Res.
- 2014 Mar;49(1):22-28.
- doi: 10.5045/br.2014.49.1.22
BACKGROUND: The coexistence of t(9;22)(q34;q11.2) and inv(16)(p13q22) chromosomal abnormalities is extremely uncommon, and only a small number of such cases have been reported. Here, we characterized 7 cases of hematologic... -
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- Immunohistochemical Classification of Primary and Secondary Glioblastomas
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Lee KS, Choe G, Nam KH, Seo AN, Yun S, Kim KJ, Cho HJ, Park SH
- KMID: 2012155
- Korean J Pathol.
- 2013 Dec;47(6):541-548.
BACKGROUND: Glioblastomas may develop de novo (primary glioblastomas, P-GBLs) or through progression from lower-grade astrocytomas (secondary glioblastomas, S-GBLs). The aim of this study was to compare the immunohistochemical classification of... -
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- Characterization and Prognostic Value of Mutations in Exons 5 and 6 of the p53 Gene in Patients with Colorectal Cancers in Central Iran
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Golmohammadi R, Namazi MJ, Nikbakht M, Salehi M, Derakhshan MH
- KMID: 1431344
- Gut Liver.
- 2013 May;7(3):295-302.
- doi: 10.5009/gnl.2013.7.3.295
BACKGROUND/AIMS: We aimed to investigate the relation-ships among various mutations of the p53 gene and their protein products, histological characteristics, and disease prognosis of primary colorectal cancer in Isfahan, central... -
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- Cancer cells with p53 deletion detected by fluorescent in situ hybridization in peritoneal drainage fluid is correlated with early peritoneal seeding in resectable pancreatic cancer
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Kang MJ, Han SS, Jang JY, Park JW, Kwon W, Chang YR, Kim SW
- KMID: 2212465
- J Korean Surg Soc.
- 2013 Apr;84(4):209-215.
- doi: 10.4174/jkss.2013.84.4.209
PURPOSE: Free tumor cells in peritoneal fluid in patients with pancreatic cancer may have prognostic significance but there are few reports on methods for the effective detection of free tumor... -
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- Overexpression of Periostin Protein in Non-Small Cell Lung Carcinoma is Not Related with Clinical Prognostic Significance
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Park WY, Shin DH, Kim JH, Lee MK, Lee HS, Lee CH
- KMID: 2319732
- Tuberc Respir Dis.
- 2012 Feb;72(2):132-139.
BACKGROUND: Periostin is preferentially expressed in periosteum, indicating a potential role in bone formation. Recently, there have been emerging controversies about its role in invasion and metastasis of human malignancies.... -
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- Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer
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Bae EY, Lee EJ, Kang HG, Lee SY, Jin G, Lee WK, Choi JE, Jeon HS, Lim JO, Lee EB, Park JY
- KMID: 1123458
- J Korean Med Sci.
- 2011 Nov;26(11):1527-1530.
- doi: 10.3346/jkms.2011.26.11.1527
Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby... -
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- Analysis of TP53 Gene Mutations in the Korean Patients with Lung Cancer
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Jung SB, Chang HK, Choi SC, Shin KC, Lee KH, Jeon CH
- KMID: 1993638
- Lab Med Online.
- 2011 Oct;1(4):202-208.
- doi: 10.3343/lmo.2011.1.4.6
BACKGROUND: Lung cancer is one of the leading causes of cancer-related deaths throughout the world. The gene tumor protein 53 (TP53) is frequently mutated in cases of lung cancer. This... -
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- Arg72Pro Polymorphism and Exon 7 Codon 249 Mutation of Plasma DNA p53 Gene in Early Hepatocellular Carcinoma Patients with Hepatitis B Virus Infection in a Korean population
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Park Y, Lee JH, Lee EY, Kim HS
- KMID: 2200544
- J Lab Med Qual Assur.
- 2010 Dec;32(2):255-262.
BACKGROUND: This study was performed to investigate on the genotypic frequencies of p53 Arg72Pro polymorphism and the prevalence of p53 codon 249 mutation in hepatocellular carcinoma patients. METHODS: Plasma DNAs were... -
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- Genetic and Expression Analysis of the SIRT1 Gene in Gastric Cancers
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Cao Z, Song JH, Kang YW, Yoon JH, Nam SW, Lee JY, Park WS
- KMID: 2372605
- J Gastric Cancer.
- 2010 Sep;10(3):91-98.
PURPOSE: Silent mating-type information regulation 2 homologue 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. SIRT1 plays an important role in the regulation of cell death/survival and stress response in... -
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- Blastoid Mantle Cell Lymphoma: A Case Report
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Shin JW, Yang JH, Lee SY, Lee JS, Park YL, Cho MK, Cho HD
- KMID: 2301848
- Korean J Dermatol.
- 2010 Aug;48(8):684-688.
Mantle cell lymphoma (MCL) is a low-grade malignant lymphoma derived from a subset of B-cells localized in the mantle zone of the lymphoid follicle. MCL commonly involves extranodal sites, usually... -
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- Role of Loss of O(6)-Methylguanine DNA Methyltransferase (MGMT) Expression in Non-Small Cell Lung Carcinomas (NSCLCs): with Reference to the Relationship with p53 Overexpression
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Myong NH
- KMID: 2165964
- Cancer Res Treat.
- 2010 Jun;42(2):95-100.
PURPOSE: Functional inactivation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene has been demonstrated as loss of MGMT protein and suggested that it plays an important role in primary human neoplasia, including... -
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