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Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway

Liang Y, Wang S, Liu J

PURPOSE: Tumor protein p53-regulated apoptosis-inducing protein 1 (TP53AIP1) functions in various cancers. We studied the effect and molecular mechanism of TP53AIP1 in breast cancer. METHODS: The degree of correlation between TP53AIP1...
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Expression of p63 and its association with cell proliferation at different stages of murine hair follicle cycle

Lee BW, Oh JW, Seo M, Hwang JS, Yoon B

In the present study, we investigated the expression patterns of p63, a member of the p53 gene family, in hair follicle cells at different stages of the hair cycle and...
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Development of Urinary Bladder Pre-Neoplasia by Schistosoma haematobium Eggs and Chemical Carcinogen in Mice

Chala B, Choi MH, Moon KC, Kim HS, Kwak C, Hong ST

Schistosoma haematobium is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting S. haematobium eggs into the bladder wall and introduction...
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The Evaluation of p53 Polymorphism at Codon 72 and Association With Breast Cancer in Iran: A Systematic Review and Meta-analysis

Soleimani , Rahmani Y, Farshchian N, Delpisheh , Khassi K, Shahmohammadi A, Amirifard

BACKGROUND: Breast cancer is the most common cancer among women in Iran and the world. Multiple environmental factors and genetic variations such as genetic polymorphisms are of its main causes....
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Cryopreservation of Human Wharton's Jelly-derived Mesenchymal Stem Cells Following Controlled Rate Freezing Protocol Using Different Cryoprotectants; A Comparative Study

Shivakumar SB, Bharti D, Jang SJ, Hwang SC, Park JK, Shin JK, Byun JH, Park BW, Rho GJ

OBJECTIVES: To compare the effect of three different cryoprotectants on basic stem cell characteristics for the possibility of using well defined, dimethyl sulfoxide (DMSO) and serum free freezing solutions to...
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p53 Expression in a Malignant Mesothelioma Patient during Seven-Year Follow-up

Koo SM, Uh ST, Kim DW, Kim KU, Kim YK

  • KMID: 2320518
  • Tuberc Respir Dis.
  • 2014 Jun;76(6):284-288.
Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies....
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Patterns and Biologic Features of p53 Mutation Types in Korean Breast Cancer Patients

Kim HW, Lee HM, Hwang SH, Ahn SG, Lee KA, Jeong J

  • KMID: 2353077
  • J Breast Cancer.
  • 2014 Mar;17(1):1-7.
PURPOSE: The p53 gene is one of the most frequently mutated genes in breast cancer. We investigated the patterns and biologic features of p53 gene mutation and evaluated their clinical...
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Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors

Kim JH, Choi KY, Lee DJ, Rho YS, Jo SJ

  • KMID: 2278408
  • Clin Exp Otorhinolaryngol.
  • 2014 Mar;7(1):53-58.
OBJECTIVES: To evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors. METHODS: Eighty thyroid tumor cases...
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Characteristics of hematologic malignancies with coexisting t(9;22) and inv(16) chromosomal abnormalities

Han E, Lee H, Kim M, Kim Y, Han K, Lee SE, Kim HJ, Kim DW

BACKGROUND: The coexistence of t(9;22)(q34;q11.2) and inv(16)(p13q22) chromosomal abnormalities is extremely uncommon, and only a small number of such cases have been reported. Here, we characterized 7 cases of hematologic...
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Osteosarcoma with Adenocarcinoma of Lung in Li-Fraumeni Syndrome: A Case Report

Oh CS, Lee JH, Jung ST, Na BR

Li-Fraumeni syndrome (LFS) is an autosomal dominant hereditary disorder characterised by a variety of different tumor types in children and young adults. That contains with a germline mutation in the...
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Characterization and Prognostic Value of Mutations in Exons 5 and 6 of the p53 Gene in Patients with Colorectal Cancers in Central Iran

Golmohammadi R, Namazi MJ, Nikbakht M, Salehi M, Derakhshan MH

BACKGROUND/AIMS: We aimed to investigate the relation-ships among various mutations of the p53 gene and their protein products, histological characteristics, and disease prognosis of primary colorectal cancer in Isfahan, central...
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Cancer cells with p53 deletion detected by fluorescent in situ hybridization in peritoneal drainage fluid is correlated with early peritoneal seeding in resectable pancreatic cancer

Kang MJ, Han SS, Jang JY, Park JW, Kwon W, Chang YR, Kim SW

PURPOSE: Free tumor cells in peritoneal fluid in patients with pancreatic cancer may have prognostic significance but there are few reports on methods for the effective detection of free tumor...
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Immunohistochemical Classification of Primary and Secondary Glioblastomas

Lee KS, Choe G, Nam KH, Seo AN, Yun S, Kim KJ, Cho HJ, Park SH

  • KMID: 2012155
  • Korean J Pathol.
  • 2013 Dec;47(6):541-548.
BACKGROUND: Glioblastomas may develop de novo (primary glioblastomas, P-GBLs) or through progression from lower-grade astrocytomas (secondary glioblastomas, S-GBLs). The aim of this study was to compare the immunohistochemical classification of...
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Overexpression of Periostin Protein in Non-Small Cell Lung Carcinoma is Not Related with Clinical Prognostic Significance

Park WY, Shin DH, Kim JH, Lee MK, Lee HS, Lee CH

  • KMID: 2319732
  • Tuberc Respir Dis.
  • 2012 Feb;72(2):132-139.
BACKGROUND: Periostin is preferentially expressed in periosteum, indicating a potential role in bone formation. Recently, there have been emerging controversies about its role in invasion and metastasis of human malignancies....
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Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer

Bae EY, Lee EJ, Kang HG, Lee SY, Jin G, Lee WK, Choi JE, Jeon HS, Lim JO, Lee EB, Park JY

Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby...
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Analysis of TP53 Gene Mutations in the Korean Patients with Lung Cancer

Jung SB, Chang HK, Choi SC, Shin KC, Lee KH, Jeon CH

BACKGROUND: Lung cancer is one of the leading causes of cancer-related deaths throughout the world. The gene tumor protein 53 (TP53) is frequently mutated in cases of lung cancer. This...
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Genetic and Expression Analysis of the SIRT1 Gene in Gastric Cancers

Cao Z, Song JH, Kang YW, Yoon JH, Nam SW, Lee JY, Park WS

  • KMID: 2372605
  • J Gastric Cancer.
  • 2010 Sep;10(3):91-98.
PURPOSE: Silent mating-type information regulation 2 homologue 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. SIRT1 plays an important role in the regulation of cell death/survival and stress response in...
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Blastoid Mantle Cell Lymphoma: A Case Report

Shin JW, Yang JH, Lee SY, Lee JS, Park YL, Cho MK, Cho HD

  • KMID: 2301848
  • Korean J Dermatol.
  • 2010 Aug;48(8):684-688.
Mantle cell lymphoma (MCL) is a low-grade malignant lymphoma derived from a subset of B-cells localized in the mantle zone of the lymphoid follicle. MCL commonly involves extranodal sites, usually...
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Role of Loss of O(6)-Methylguanine DNA Methyltransferase (MGMT) Expression in Non-Small Cell Lung Carcinomas (NSCLCs): with Reference to the Relationship with p53 Overexpression

Myong NH

  • KMID: 2165964
  • Cancer Res Treat.
  • 2010 Jun;42(2):95-100.
PURPOSE: Functional inactivation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene has been demonstrated as loss of MGMT protein and suggested that it plays an important role in primary human neoplasia, including...
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The expression of survivin and its related genes in adipocyte-derived stem cell by demethylation

Yoon K, Lim YS, Yu SB, Kim DS, Ryu SJ, Kim KH, Jang TH, Kim SH

BACKGROUND: Survivin is thought to contribute to stem cell maintenance partly by a hypomethylation mechanism. This study attempted to elucidate the signal transduction pathway of adipocyte-derived stem cells (ASCs) by...
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