Korean J Pediatr Gastroenterol Nutr.  2005 Sep;8(2):117-121.

Elevated Serum Creatine Kinase Level in Rotavirus Gastroenteritis

Affiliations
  • 1Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Korea. seozee@gshp.gsnu.ac.kr

Abstract

PURPOSE: Elevated AST/ALT level in rotavirus gastroenteritis have been reported. We found elevated creatine kinase (CK) in those children. This study was carried out to define the relationship of major clinical presentation, laboratory findings, and level of creatine kinase.
METHODS
A retrospective analysis was made for thirty patients who were diagnosed rotavirus gastroenteritis from Jan 2001 to Mar 2005 in Department of Pediatrics, Gyeongsang National University Hospital. Serum creatine kinase was checked for the evaluation of high aminotransferase level among the patients.
RESULTS
Fourteen patients (8 males, 6 females) with high creatine kinase activity were included in this study. The mean age was 1.46+/-1.24 year of age. The mean level of AST, ALT and CK were 127.5+/-136.2 IU/L, 126.1+/-154.3 IU/L, and 542.8+/-624.6 IU/L, respectively. Electrophoresis of CK isoenzyme was performed in four of them and the results revealed elevated CK-MM fraction (96~100%). Three of them revealed high serum creatine kinase acitivity (>1,000 IU/L) without acute renal failure and other symptom. However, none of them had muscular pain or trauma history. Elevated creatine kinase activity did not correlate with clinical implications (age, sex, vomiting, diarrhea, fever, symptom of URI, degree of dehydration or seizure) or laboratory findings.
CONCLUSION
In this study, we found that serum creatine kinase acitivity also was elevated in infants with rotavirus gastroenteritis. This data support muscular damage due to rotavirus, but could not prove the mechanism of increased serum creatine kinase activity.

Keyword

Rotavirus; Transaminases; Creatine kinase

MeSH Terms

Acute Kidney Injury
Child
Creatine Kinase*
Creatine*
Dehydration
Diarrhea
Electrophoresis
Fever
Gastroenteritis*
Humans
Infant
Male
Pediatrics
Retrospective Studies
Rotavirus*
Transaminases
Vomiting
Creatine
Creatine Kinase
Transaminases
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