Chonnam Med J.
1997 Dec;33(2):305-310.
A Case of Type 1 Autoimmune Hepatitis
- Affiliations
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- 1Department of Internal Medicine, Kwangju Veterans Hospital, Kwangju, Korea.
- 2Department of Pathology, Kwangju Veterans Hospital, Kwangju, Korea.
Abstract
- A 59 year-old female was admitted to the hospital due to generalized myalgia, febrile sensation, and discomfort of right upper abdomen. She had taken the medicine for 2 years intermittently due to knee joint pain and stopped 10 days before admission. Her liver function test was abnormal and after then improved during treatment under the impression of drug-induced hepatitis, but sudden aggravated at 20th admission day. The liver biopsy performed for the further evaluation of sudden aggravation of liver function. It showed periportal hepatitis, piecemeal necrosis, fibrosis, and chronic inflammatory cell infiltration in the lobule suggestive chronic lobular hepatitis. Laboratory test showed hypergammaglobulinemia and antismooth muscle Ab without evidence of viral infection. We report this case as a type 1 auto- immune hepatitis with good response to corticosteroid with a literature review.
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