J Korean Pediatr Soc.
1998 Jul;41(7):979-983.
A Case of Type I Autoimmune Hepatitis in Children
- Affiliations
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- 1Department of Pediatrics, College of Medicine, Pusan National University, Pusan, Korea.
Abstract
- Autoimmune hepatitis is an inflammatory liver disease characterized histologically by a dense mononuclaear cell infiltration of the portal tract, serologically by the presence of non-organ and liver specific autoantibodies and increased concentrations of IgG in the absence of a known etiology. Two types of autoimmune hepatitis are classified in the peripheral blood of antinuclear antibody and/or in antismooth muscle antibody (ANA/ASMA) or liver-kidney microsomal type 1 antibody (LKM-1). Type I (ANA/ASMA positive) and type II (LKM-1 positive) autoimmune hepatitis in children have clinical, biochemical, and histologic differences. We have experienced a case of type I autoimmune hepatitis in a 9-year-old girl. She had shown highly elevated IgG, high serum transaminase and marked hepatosplenomegaly. And so serologically ANA and ASMA were positive, histological findings of the liver biopsy were compatible with chronic active hepatitis. She was medicated with prednisone, but symptoms did not improved. Now she is receving conservative regimens.
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