Chonnam Med J.
2003 Jun;39(2):85-92.
Total Peroxyl Radical-Trapping Ability of Venous Plasma and Amniotic Fluid of Pregnant Women in Preterm Labor with Intact Membranes
- Affiliations
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- 1Department of Obstetrics and Gynecology, Chonnam National University Medical School, Korea. kimyh@chonnam.ac.kr
- 2Department of Biochemistry, Chonnam National University Medical School, Korea.
- 3Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea.
- 4Department of Obstetrics and Gynecology, St. Carollo Hospital, Sunchon, Korea.
Abstract
- The aim of this study was to evaluate the role of antioxidants in the pathophysiology of preterm labor, and the levels of TRAP values, antioxidant vitamins, as well inflammatory cytokines were determined in the amniotic fluid of pregnant women with preterm labor with intact membranes and of these of normal pregnancy. Cytokine levels in the amniotic fluid of pregnant women in preterm labor with intact membranes (IL-6: 12.11+/-5.19 ng/ml, IL-8: 8.36+/-2.94 ng/ml) were significantly higher than those of normal pregnant women (IL-6: 0.62+/-0.32 ng/ml, IL-8: 0.55+/-0.15 ng/ml) (p<0.01). TRAP values in the amniotic fluid of preterm labor and intact membranes were significantly lower than that of normal pregnancy (0.48+/-0.04 mM vs. 0.62+/-0.03 mM, p<0.01). Amniotic fluid ascorbic acid levels of pregnant women with preterm labor and intact membranes were significantly lower than that of normal pregnant women (126.3+/-14.5 nmol/ml vs. 209.3+/-25.5 nmol/ml, p<0.01). There were no significant differences in maternal venous blood plasma TRAP values, uric acid, retinol, alpha-tocopherol, and gamma-tocopherol levels between both groups. This findings suggest that decreased antioxidant activity in the amniotic fluid may be involved in the pathophysiology of preterm labor and demonstrate that the antioxidant vitamin, ascorbic acid, may act as an important factor in the prevention of preterm labor.
Keyword
MeSH Terms
-
alpha-Tocopherol
Amniotic Fluid*
Antioxidants
Ascorbic Acid
Cytokines
Female
gamma-Tocopherol
Humans
Interleukin-8
Membranes*
Obstetric Labor, Premature*
Plasma*
Pregnancy
Pregnant Women*
Uric Acid
Vitamin A
Vitamins
Antioxidants
Ascorbic Acid
Cytokines
Interleukin-8
Uric Acid
Vitamin A
Vitamins
alpha-Tocopherol
gamma-Tocopherol
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