Korean J Otolaryngol-Head Neck Surg.  1998 Aug;41(8):1029-1033.

Effects of Preoperative Midazolam and Ketorolac Tromethamin Treatment in Septoplasty

Affiliations
  • 1Department of Otorhinolaryngology, College of Medicine, Yonsei University, Seoul, Korea. johnsskim@yumc.yonsei.ac.kr
  • 2Department of Anesthesiology, College of Medicine, Yonsei University, Seoul, Korea.

Abstract

BACKGROUND AND OBJECTIVES: This study was to investigate the effect of preoperative administration of midazolam and ketorolac for postoperative pain and antegrade amnesia in septoplasty under local anesthesia.
MATERIALS AND METHODS
We studied 40 patients who underwent septoplasty under local anesthesia. The patients were divided into four groups, each consisting 10 patients (N=40). The groups received different treatment, with the first group receiving ketorolac, the second group ketorolac and diazepam, and the third group ketorolac and midazolam. The fourth group received midazolam only. Postoperative pain was evaluated according to Verbal Rating Pain Scores (VRP), and Visual Analogue Pain Scores (VAS) at 2, 4, 6, 12, 24 and 48 hours after operation. Antegrade amnesia was evaluated also.
RESULTS
Postoperative pain was decreased at 6, 12, 24 hours in the third and fourth group. Antegrade amnesia was noted in the third and fourth group. The third group showed strong antegrade amnesia.
CONCLUSION
Preoperative administration of ketorolac and midazolam were effective for postoperative pain and antegrade amnesia in septoplasty.

Keyword

Ketorolac tromethamin; Midazolam; Postoperative pain; Antegrade amnesia

MeSH Terms

Amnesia
Anesthesia, Local
Diazepam
Humans
Ketorolac*
Midazolam*
Pain, Postoperative
Diazepam
Ketorolac
Midazolam
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