Korean J Obstet Gynecol.  2002 Dec;45(12):2172-2176.

Twin Pregnancies: In Vitro Fertilization vs. Spontaneously Conceived

Affiliations
  • 1Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.

Abstract


OBJECTIVE
To compare the obstetrical and perinatal outcomes of twin pregnancies after IVF-ET with those of twin pregnancies conceived spontaneously.
METHODS
Two hundred and six cases of IVF-ET twin pregnancies (IVF group) were compared with 229 spontaneously conceived or ovulation induced twin pregnancies (spontaneously conceived group) for obstetrical and perinatal outcomes. All were delivered between July 1994 and February 2002 at Ajou University Hospital. Their clinical records were reviwed.
RESULTS
The mean maternal age of IVF group and spontaneously conceived group was 30.7+/-3.7 years, 28.4+/-4.0 years and primiparous women were 86.9%, 58.5% (p=0.000). In IVF group and spontaneously conceived group, mean gestational age was 35.0+/-1.7 weeks, 35.5+/-2.1 weeks (P=0.000), mean birth weight 2311.4+/-411.7 gm, 2324.3+/-447.1 gm (P=0.015), and frequency of birth weight less than 2500 gm 70.6%, 60.3% (p=0.001). In both groups, the frequencies for preterm labor, preeclampsia, intrauterine growth restriction, and birth weight discordancy were 42.2%, 32.3% (p=0.032), 8.3%, 18.3% (p=0.002), 5.3%, 8.7% (p=0.052%), 7.8%, 10.9% (p=0.262), respectively. On the comparison of the chorionicity, monochorion- diamnion was 2.0%, 36.3% (p=0.000) and dichorion-diamnion was 98.0%, 62.8% (p=0.000). And there was no significant difference in congenital anomaly, Apgar scores, frequency and duration of neonatal intensive care unit admission.
CONCLUSION
In IVF-ET twin group compared with spontaneously conceived group, there was higher incidence of preterm labor, and low birth weight.

Keyword

IVF-ET twin; Spontaneously conceived twin; Perinatal outcomes

MeSH Terms

Birth Weight
Chorion
Female
Fertilization in Vitro*
Gestational Age
Humans
Incidence
Infant, Low Birth Weight
Infant, Newborn
Intensive Care, Neonatal
Maternal Age
Obstetric Labor, Premature
Ovulation
Pre-Eclampsia
Pregnancy
Pregnancy, Twin*
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