Korean J Med.  2014 Oct;87(4):491-495. 10.3904/kjm.2014.87.4.491.

A Case of Acute Tubular Necrosis and Hearing Loss Induced by Intravenous Administration of Ciprofloxacin

• Kim JJ
• Kim HJ
• Kim SH
• Park WD

• KMID: 2269227
• DOI: http://doi.org/10.3904/kjm.2014.87.4.491

Abstract

Ciprofloxacin is a broad-spectrum antibiotic used to treat a variety of infections. However, acute kidney injury is a rarely reported side effect. Ciprofloxacin-related nephrotoxicity typically manifests as acute tubulointerstitial nephritis. To the best of our knowledge, few cases of acute tubular necrosis as a complication of ciprofloxacin have been reported to date. We herein describe a case involving a 41-year-old woman treated with intravenous ciprofloxacin at 200 mg twice daily for gastroenteritis. One day after initiation of treatment, her serum creatinine level increased from 0.95 to 3.83 mg/dL and she experienced impaired hearing. Five days later, renal biopsy demonstrated acute tubular necrosis. The acute tubular necrosis encountered in this patient resolved; however, short-term hemodialysis was required. This is the first reported case of acute kidney injury associated with ciprofloxacin use in Korea.

Keyword

Ciprofloxacin; Acute kidney injury; Acute tubular necrosis; Hearing loss

MeSH Terms

Acute Kidney Injury
Administration, Intravenous*
Adult
Biopsy
Ciprofloxacin*
Creatinine
Female
Gastroenteritis
Hearing
Hearing Loss*
Humans
Korea
Necrosis*
Nephritis, Interstitial
Renal Dialysis
Ciprofloxacin
Creatinine