Korean J Med.
2016 Jan;90(1):63-67. 10.3904/kjm.2016.90.1.63.
Myelodysplastic Syndrome and Minimal Change Nephrotic Syndrome treated with Steroid Challenge
- Affiliations
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- 1Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea. mozarteffect@hanmail.net
- 2Department of Laboratory Medicine, Daegu Fatima Hospital, Daegu, Korea.
- 3Department of Pathology, Daegu Fatima Hospital, Daegu, Korea.
- KMID: 2268894
- DOI: http://doi.org/10.3904/kjm.2016.90.1.63
Abstract
- Glomerulonephritis associated with malignancy is deemed to be paraneoplastic glomerulonephritis. Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal hematopoietic stem cell disorders characterized by impaired hematopoietic cell differentiation and cytopenia. The pathophysiology of MDS is thought to be immune-mediated in part. A few reports have documented various forms of glomerulonephritis in patients with MDS and suggested that immune dysregulation is important in the development of paraneoplastic glomerulonephritis. Here, we report a patient with MDS and refractory anemia with excess blast-2 accompanied by minimal change nephrotic syndrome. The patient was treated with prednisolone, and the nephrotic-range proteinuria and pancytopenia improved markedly.
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