Ann Dermatol.  2010 Aug;22(3):319-322. 10.5021/ad.2010.22.3.319.

A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus

  • 1Department of Dermatology, Eulji Medical Center, College of Medicine, Eulji University, Seoul, Korea.
  • 2Department of Pathology, Eulji Medical Center, College of Medicine, Eulji University, Seoul, Korea.


Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor. TAA and syringocystadenoma papilliferum (SCAP) rarely develop together in a nevus sebaceus (NS). Herein, we report on a 40-year-old Korean woman with TAA associated with SCAP that developed in a NS located on the scalp.


Nevus sebaceus; Syringocystadenoma papilliferum; Tubular apocrine adenoma

MeSH Terms

Sweat Glands


  • Fig. 1 A solitary, 2.5×2.5 cm well-circumscribed, erosive, erythematous lobulated nodule on the scalp.

  • Fig. 2 Syringocystadenoma papilliferum in the upper portion of the lesion and tubular apocrine adenoma in the lower portion (H&E, ×12.5).

  • Fig. 3 Findings of the upper part of the lesion. (A) Cystic and irregularly dilated tubular structures with deep invagination (H&E, ×200). (B) The lumina are lined by 2 layers of epithelial cells embedded in a fibroblastic stroma with a plentiful plasma cell infiltration (H&E, ×400).

  • Fig. 4 Findings of the lower part of the lesion. (A) Variable sized tubular structures are seen (H&E, ×100). (B) Two layers of cells with evidence of decapitation secretion of the luminal cells are seen (H&E, ×400).

  • Fig. 5 (A) Only focally positive staining results in the syringocystadenoma papilliferum (SCAP) lesion (GCDFP-15, ×100). (B) Strong positive staining results in the tubular apocrine adenoma (TAA) lesion (GCDFP-15, ×200).

Cited by  3 articles

Syringocystadenoma Papilliferum of the Back Combined with a Tubular Apocrine Adenoma
Hyun Joo Lee, Eujin Cho, Min Ho Kim, Sang Hyun Cho, Jeong Deuk Lee
Ann Dermatol. 2011;23(Suppl 2):S151-S154.    doi: 10.5021/ad.2011.23.S2.S151.

Syringocystadenoma Papilliferum in Co-existence with Tubular Apocrine Adenoma on the Calf
Jung Hee Yoon, Hyo Hyun Ahn, Young Chul Kye, Soo Hong Seo
Ann Dermatol. 2011;23(Suppl 2):S175-S178.    doi: 10.5021/ad.2011.23.S2.S175.

Syringocystadenocarcinoma Papilliferum: A Case Report and Review of the Literature
Kyoung Geun Lee, Won Choi, Joon Soo Lim, Hyung Jin Hahn, Ki Bum Myung, Seung Hyun Cheong
Ann Dermatol. 2019;31(5):559-562.    doi: 10.5021/ad.2019.31.5.559.


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