Allergy Asthma Respir Dis.  2013 Dec;1(4):388-390. 10.4168/aard.2013.1.4.388.

Churg-Strauss syndrome presenting as acute acalculous cholecystitis

  • 1Department of Internal Medicine, Samsung Medical Center, Seoul, Korea.
  • 2Department of Pathology, Samsung Medical Center, Seoul, Korea.
  • 3Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.


Churg-Strauss syndrome (CSS) is a rare systemic vasculitis. It is characterized by peripheral eosinophilia, asthma, neuropathy, skin manifestation, and less frequently gastrointestinal tract symptoms. Here we report a case of CSS which is initially manifested as acute acalculous cholecystitis. A 67-year-old asthmatic woman visited Emergency Room because of acute abdominal pain. Computed tomography showed acalculous cholecystitis and laparoscopic cholecystectomy was done. Pathology of gallbladder showed marked eosinophilic infiltration with necrotizing vasculitis and granuloma. On the basis of asthma, sinusitis, lung infiltration, combined peripheral eosinophilia and neuropathy, the patient was diagnosed as CSS. To our knowledge, this is the first case of pathologically proven eosinophilic cholecystitis in Korea.


Churg-Strauss syndrome; Acalculous cholecystitis; Vasculitis
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