Korean J Obstet Gynecol.  2002 Jan;45(1):45-50.

The Significance of Normal 100 gm Oral Glucose Tolerance Test on Perinatal Outcomes

• Lee WJ
• Sohn BC
• Kim HS
• Yang JI
• Yang SC
• Jo MY
• Ryou JM
• Oh KS
• Ryu HS

Abstract

OBJECTIVE
To evaluate perinatal outcomes in patients with abnormal 50 gm challenge test followed by normal 100 gm oral glucose tolerance test (OGTT) value.
METHODS
We examined the pregnancy outcomes of 423 women classified as the study group with abnormal 50 gm oral glucose challenge test (OGCT) followed by normal 100 gm OGTT based on NDDG criteria. If the 1-hour plasma glucose value of 50 gm OGCT was over 130 mg/dL, the patient was scheduled for a full 3-hour 100 gm OGTT. 50 gm OGCT and 100 gm OGTT were administered at 24-28 and 28-32 weeks' gestation, respectively. The control group constituted of 467 age- and body mass index (BMI)-matched negative screenees. We defined poor maternal outcomes as those suffering from any one of hydramnios or oligohydramnios, preeclampsia, cesarean delivery due to cephalopelvic disproportion, dystocia, or fetal distress. We also defined poor neonatal outcomes as those suffering from any one of hyperbilirubinemia, hypoglycemia, congenital anomaly, admission to neonatal intensive care unit due to respiratory distress syndrome, or perinatal mortality. Retrospective review of outcomes of these patients was performed. Student t-test, Fisher's exact test and chi-square test were used to determine the statistical significance.
RESULTS
There were no significant differences in demographic and obstetric characteristics between the control group and the study group. There were no significant differences in gestational age (38.7+/-1.5 vs 38.5+/-1.5 weeks), birth weight (3189.2+/-420.9 vs 3236.7+/-423.1 gm), between the groups. And there were no significant differences in preterm birth (6.2% vs 7.4%), large for gestational age births (4.5% vs 5.0%), intrauterine growth restriction (5.4% vs 4.3%) between the groups. There were no significant differences in poor maternal outcomes (15.6% vs 18.7%) and poor neonatal outcomes (3.9% vs 5.7%) between the groups.
CONCLUSION
We conclude that abnormal value on 50 gm challenge test followed by normal 100 gm OGTT is not associated with adverse perinatal outcomes.

Keyword

Normal 100 gm oral glucose tolerance test; Perinatal outcomes

MeSH Terms

Birth Weight
Blood Glucose
Body Mass Index
Cephalopelvic Disproportion
Dystocia
Female
Fetal Distress
Gestational Age
Glucose
Glucose Tolerance Test*
Humans
Hyperbilirubinemia
Hypoglycemia
Infant, Newborn
Intensive Care, Neonatal
Oligohydramnios
Parturition
Perinatal Mortality
Polyhydramnios
Pre-Eclampsia
Pregnancy
Pregnancy Outcome
Premature Birth
Retrospective Studies
Glucose