Korean J Nutr.
2007 Dec;40(8):708-718.
The Effect of Alpha-tocopherol Supplementation on the Improvement of Antioxidant Status and Lymphocyte DNA Damage in Postmenopausal Women
- Affiliations
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- 1Department of Food & Nutrition, Daedeok Valley Campus, Hannam University, Daejeon 305-811, Korea. mhkang@hnu.kr
- 2Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea.
- 3Research Institute of Clinical Nutrition, Kyung Hee University, Seoul 130-701, Korea.
Abstract
- The purpose of this project was to evaluate whether vitamin E supplementation could improve the antioxidant status and lymphocyte DNA damage in Korean postmenopausal women. This was double blinded, placebo-controlled trial. Thirty-five subject were randomized to receive either placebo 400 mg/capsule or natural alpha-tocopherol 400 IU/capsule, 2 times a day for 6 weeks. We measured plasma vitamin C, alpha-tocopherol, gamma-tocopherol, alpha-carotenoid, beta-carotenoid, lycopene concentration and tail length, %DNA in tail, tail moment in lymphocyte DNA damage index. Vitamin E supplementation group had significantly increased plasma vitamin C (p < 0.05), alpha-tocopherol (p < 0.000), whereas gamma-tocopherol (p < 0.000) and tail length (p < 0.05) were significantly decreased. However, placebo supplementation group also had significantly increased plasma vitamin C (p < 0.05). In conclusion, our study shows that vitamin E supplementation to Korean postmenopausal women may partially improve antioxidant status and lymphocyte DNA damage.
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