Korean J Med.  2008 Feb;74(2):146-153.

Expression of claudin-1, beta-catenin and E-cadherin in adenocarcinoma of the colon

• Cha EJ
• Jang KY
• Choi HN
• Kim KR
• Choi KH
• Hwang SH
• Moon WS
• Kang MJ
• Lee DG

Abstract

BACKGROUND/AIMS: Disruption of the cell-to-cell junction with changes in the expression of the junctional proteins is the hallmark of cancer invasion and metastasis. To investigate the roles of claudin-1, beta-catenin and E-cadherin in adenocarcinoma of the colon, the relationship of their expression with clinical and pathological factors were examined.
METHODS
The expression of claudin-1, beta-catenin and E-cadherin were examined in 47 cases of adenocarcinoma of the colon by immunohistochemical staining.
RESULTS
A reduced claudin-1 expression was associated with advanced lymph node metastasis (p=0.019) and histological dedifferentiation at the invasive front (p=0.030). A reduced expression of beta-catenin and E-cadherin were correlated with histological dedifferentiation (p=0.012, p=0.010, respectively). The reduced expression of two or more proteins was correlated with the histological findings of dedifferentiation (p=0.030).
CONCLUSIONS
These results suggest that loss of claudin-1, beta-catenin and E-cadherin expression may be correlated with the progression of adenocarcinoma of the colon and associated with an advanced histological grade.

Keyword

Colon; Adenocarcinoma; Claudin 1; beta Catenin; E-cadherins

MeSH Terms

Adenocarcinoma
beta Catenin
Cadherins
Claudin-1
Colon
Lymph Nodes
Neoplasm Metastasis
Proteins
Cadherins
Claudin-1
Proteins
beta Catenin